Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
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DOI：
10.1073/pnas.1232392100
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发表时间：
2003-06-24
影响因子：
11.1
通讯作者：
Teale, A
中科院分区：
文献类型：
--
作者：
Hanotte, O;Ronin, Y;Teale, A
锥虫病，或昏睡病，是撒哈拉以南非洲牲畜生产力的主要限制性疾病。为了鉴定控制牛对典型体型病抗性的数量性状基因座（QTL），在抗锥虫的非洲N 'Dama（Bos taurus）和对锥虫敏感的改良肯尼亚Boran（Bos indicus）牛之间进行了实验性杂交。定义了16个表型性状，描述贫血、体重和寄生虫血症。177个F-2动物和他们的父母和祖父母的基因型在477个分子标记位点覆盖所有29头牛常染色体。总基因组覆盖率为82%。将推定的QTL定位到18个常染色体上，
Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to typanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and trypanosusceptible improved Kenya Boran (Bos indicus) cattle. Sixteen phenotypic traits were defined describing anemia, body weight, and parasitemia. One hundred seventy-seven F-2 animals and their parents and grandparents were genotyped at 477 molecular marker loci covering all 29 cattle autosomes. Total genome coverage was 82%. Putative QTL were mapped to 18 autosomes at a genomewise false discovery rate of