Quantitative hepatitis B core antibody levels in the natural history of hepatitis B virus infection
Quantitative hepatitis B core antibody levels in the natural history of hepatitis B virus infection
复制标题
乙型肝炎病毒感染自然史中乙型肝炎核心抗体水平的定量。
DOI：
10.1016/j.cmi.2014.10.002
复制
发表时间：
2015-02-01
影响因子：
14.2
通讯作者：
Xia, N. -S.
中科院分区：
文献类型：
--
作者：
Song, L. -W.;Liu, P. -G.;Xia, N. -S.
我们先前已证明，治疗前定量抗乙肝核心蛋白（qAnti - HBc）水平能够预测干扰素和核苷类似物治疗的反应，但在慢性乙型肝炎病毒（HBV）感染期间qAnti - HBc的特征仍知之甚少。为了解这一问题，我们对既往有HBV感染、隐匿性HBV感染以及处于免疫耐受期、免疫清除期、低复制期和乙肝e抗原（HBeAg）阴性肝炎期的慢性HBV感染者的qAnti - HBc水平进行了评估。乙肝表面抗原阳性者（n = 598，3.74 ± 0.90 log₁₀IU/mL）的血清qAnti - HBc水平显著高于（p < 0.001，约高1000倍）隐匿性HBV感染者，且隐匿性HBV感染组的血清qAnti - HBc水平显著高于既往HBV感染组（p < 0.001）。qAnti - HBc水平与丙氨酸氨基转移酶水平呈正相关（R = 0.663，p < 0.001），丙氨酸氨基转移酶水平异常的受试者具有更高的qAnti - HBc水平（p < 0.001）。根据宿主免疫状态，血清qAnti - HBc水平在HBV感染的不同阶段有所不同。在慢性HBV感染者中，血清qAnti - HBc水平与肝炎活动密切相关。《临床微生物学与感染》（C）2014欧洲临床微生物学和传染病学会。由爱思唯尔有限公司出版。保留所有权利。
We previously demonstrated that pretreatment quantitative anti hepatitis B core protein (qAnti-HBc) levels can predict the treatment response for both interferon and nucleoside analogue therapy, but the characteristics of qAnti-HBc during chronic hepatitis B virus (HBV) infection remain poorly understood. To understand this issue, the qAnti-HBc levels were evaluated in individuals with past HBV infection, occult HBV infection and chronic HBV infection in the immune tolerance phase, immune clearance phase, low-replicative phase and hepatitis B e antigen (HBeAg)-negative hepatitis phase. Individuals with hepatitis B surface antigen (n = 598, 3.74 +/- 0.90 log(10) IU/mL) had significantly higher (p < 0.001, approximately 1000-fold) serum qAnti-HBc levels than those who had occult HBV, and serum qAnti-HBc levels were significantly higher in the occult HBV group than in the past HBV infection group (p < 0.001). qAnti-HBc levels were positively correlated with alanine aminotransferase levels (R = 0.663, p < 0.001), and subjects with an abnormal alanine aminotransferase level had a higher qAnti-HBc level (p < 0.001). Serum qAnti-HBc level varied in different phases of HBV infection, as determined by host immune status. Serum qAnti-HBc level is strongly associated with hepatitis activity in subjects with chronic HBV infection. Clinical Microbiology and Infection (C) 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.