Molecular analysis of HLA class I (HLA-A and -B) and HLA class II (HLA-DRB1) genes in Japanese patients with multiple sclerosis (Western type and Asian type).
Molecular analysis of HLA class I (HLA-A and -B) and HLA class II (HLA-DRB1) genes in Japanese patients with multiple sclerosis (Western type and Asian type).
复制标题
日本多发性硬化症患者（西方型和亚洲型）的 HLA I 类（HLA-A 和 -B）和 HLA II 类（HLA-DRB1）基因的分子分析。
DOI：
10.1111/j.1399-0039.1998.tb03084.x
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
Takehiko Sasazuki
中科院分区：
文献类型：
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作者：
Takashi Ono;M. R. Zambenedetti;K. Yamasaki;Y. Kawano;N. Kamikawaji;H. Ito;M. Sakurai;Yasuharu Nishimura;Jun;I. Kanazawa;Takehiko Sasazuki
应用聚合酶链反应-序列特异性寡核苷酸探针分析法对146例日本多发性硬化（MS）患者的HLA-A、-B和-DRB 1基因型进行了研究。57例患者显示选择性的临床参与的视神经和脊髓被归类为亚洲型MS。其他89例患者有弥漫性中枢神经系统受累，并被归类为西方型MS。HLA-B*5101的频率增加，在这两种类型的MS患者与对照组相比。与对照组相比，西方型MS中HLA-DRB 1 *1501的频率增加，亚洲型MS中HLA-DRB 1 *0802的频率增加。校正P值后，Western型MS患者与HLA-DRB 1 *1501的关联具有统计学显著性（Pc=0.0003），而其他HLA等位基因未显示出显著关联。这些结果表明，HLA I类（HLA-A和-B）等位基因可能不会导致一个强大的易感性MS的日本相比，HLA II类（HLA-DRB 1）等位基因。
The types of HLA-A, -B and -DRB1 genes were studied in 146 Japanese patients with multiple sclerosis (MS) using polymerase chain reaction-sequence-specific oligonucleotide probe analysis. Fifty-seven patients who displayed selective clinical involvement of the optic nerve and spinal cord were classified as having Asian type MS. The other 89 patients had disseminated central nervous system involvement and were classified as having Western type MS. The frequency of HLA-B*5101 was increased in both types of MS patients compared with controls. The frequency of HLA-DRB1*1501 was increased in Western type MS and the frequency of HLA-DRB1*0802 was increased in Asian type MS compared to controls. After correction of P values, the association of Western type MS patients with HLA-DRB1*1501 was statistically significant (Pc=0.0003) whereas other HLA alleles showed no significant association. These results suggest that HLA class I (HLA-A and -B) alleles may not contribute to a strong susceptibility to MS in Japanese compared to HLA class II (HLA-DRB1) alleles.