Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis
Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis
复制标题
DOI：
10.1021/la800780w
复制
发表时间：
2008-06-03
期刊：
影响因子：
3.9
通讯作者：
Kee, Tak W.
中科院分区：
文献类型：
--
作者：
Leung, Mandy H. M.;Colangelo, Hannah;Kee, Tak W.
研究了姜黄素在由阳离子表面活性剂十六烷基三甲基溴化铵（CTAB）和十二烷基三甲基溴化铵（DTAB）和阴离子表面活性剂十二烷基硫酸钠（SDS）组成的三种胶束中的碱性水解。在 pH 13 时，姜黄素在 SDS 胶束溶液中通过碱性水解而快速降解。相比之下，在 CTAB 或 DTAB 胶束存在的情况下，姜黄素的碱性水解被大大抑制，抑制率接近 90%。荧光光谱研究的结果表明，虽然姜黄素在 pH 13 时仍封装在 C-TAB 和 DTAB 胶束中，但在此 pH 下姜黄素从 SDS 胶束解离到水相中。 SDS 胶束溶液中缺乏封装和稳定会导致姜黄素快速水解。
The alkaline hydrolysis of curcumin was studied in three types of micelles composed of the cationic surfactants cetyl trimethylammonium bromide (CTAB) and dodecyl trimethylammonium bromide (DTAB) and the anionic surfactant sodium dodecyl sulfate (SDS). At pH 13, curcumin undergoes rapid degradation by alkaline hydrolysis in the SDS micellar solution. In contrast, alkaline hydrolysis of curcumin is greatly suppressed in the presence of either CTAB or DTAB micelles, with a yield of suppression close to 90%. The results from fluorescence spectroscopic studies reveal that while curcumin remains encapsulated in C-TAB and DTAB micelles at pH 13, curcumin is dissociated from the SDS micelles to the aqueous phase at this pH. The absence of encapsulation and stabilization in the SDS micellar solution results in rapid hydrolysis of curcumin.