An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy.
An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy.
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DOI：
10.1021/nn504573u
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发表时间：
2015-01
期刊：
影响因子：
17.1
通讯作者：
Guang Yang;Jie Wang;Yi Wang;Long Li;Xing Guo;Shaobing Zhou
中科院分区：
文献类型：
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作者：
Guang Yang;Jie Wang;Yi Wang;Long Li;Xing Guo;Shaobing Zhou
纳米载体由于其优先携带药物进入癌组织的能力而在癌症治疗中引起广泛关注，但由于静脉内递送的化疗药物的全身毒性和低递送功效，其应用仍然受到限制。在这项研究中，我们开发了一种局部药物输送装置与组合的主动靶向胶束系统和可植入的聚合物纳米纤维。该装置首先通过形成由叶酸缀合的PCL-PEG共聚物组装的疏水性多柔比星（Dox）封装的活性靶向胶束来实现。然后，核-壳聚合物纳米纤维的制造实现与同轴静电纺丝，其中的核心区域由聚（乙烯醇）和胶束的混合物和外壳层由交联明胶组成。与通过反复静脉内注射胶束进行治疗剂的系统给药相比，这种可植入装置具有大大降低药物剂量、给药频率和化疗剂副作用的能力，同时保持对人工实体瘤的高度治疗功效。这种基于胶束的纳米装置可以发展成为下一代纳米医学，用于有效和安全的癌症治疗。
Nanocarriers have attracted broad attention in cancer therapy because of their ability to carry drugs preferentially into cancer tissue, but their application is still limited due to the systemic toxicity and low delivery efficacy of intravenously delivered chemotherapeutics. In this study, we develop a localized drug delivery device with combination of an active-targeting micellar system and implantable polymeric nanofibers. This device is achieved first by the formation of hydrophobic doxorubicin (Dox)-encapsulated active-targeting micelles assembled from a folate-conjugated PCL-PEG copolymer. Then, fabrication of the core-shell polymeric nanofibers is achieved with coaxial electrospinning in which the core region consists of a mixture of poly(vinyl alcohol) and the micelles and the outer shell layer consists of cross-linked gelatin. In contrast to the systematic administration of therapeutics via repeatedly intravenous injections of micelles, this implantable device has these capacities of greatly reducing the drug dose, the frequency of administration and side effect of chemotherapeutic agents while maintaining highly therapeutic efficacy against artificial solid tumors. This micelle-based nanofiber device can be developed toward the next generation of nanomedicine for efficient and safe cancer therapy.