A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma
A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma
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DOI：
10.1093/jnen/nly085
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发表时间：
2018-11-01
影响因子：
3.2
通讯作者：
LeBlanc, Amy K.
中科院分区：
文献类型：
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作者：
Koehler, Jennifer W.;Miller, Andrew D.;LeBlanc, Amy K.
美国国家癌症研究所领导的多学科比较脑肿瘤联盟（CBTC）召集了一个神经胶质瘤病理学小组，由兽医和神经病理学家组成，并对193例犬神经胶质瘤病例进行了全面审查。当前的目标是通过建立一个组织学特征图谱来改善现有的胶质瘤分类方法，从而使表型特征更加一致。长期目标是支持未来将临床结果和基因组数据纳入拟议的简化诊断方案，以进一步弥合兽医和医生神经病理学的世界，并加强犬作为人类胶质瘤自然发生的预防相关动物模型的有效性。所有病例根据整个委员会设计的新模式进行形态学重新分类，得出星形细胞瘤（43，22.3%）和少突胶质细胞瘤（134，69.4%）的多数意见诊断，其中星形细胞瘤19例为低级别，24例为高级别，少突胶质细胞瘤35例为低级别，99例为高级别。16例（8.3%）不能单独根据形态学分类为少突胶质细胞瘤或星形细胞瘤，而被指定为未定义的胶质瘤。本文提出的简化分类方案为将来添加分子数据提供了一种易于处理的方法，也有助于突出人和犬胶质瘤之间的组织学相似性和差异。
The National Cancer Institute-led multidisciplinary Comparative Brain Tumor Consortium (CBTC) convened a glioma pathology hoard, comprising both veterinarian and physician neuropathologists, and conducted a comprehensive review of 193 cases of canine glioma. The immediate goal was to improve existing glioma classification methods through creation of a histologic atlas of features, thus yielding greater harmonization of phenotypic characterization. The long-term goal was to support future incorporation of clinical outcomes and genomic data into proposed simplified diagnostic schema, so as to further bridge the worlds of veterinary and physician neuropathology and strengthen validity of the dog as a naturally occurring, translationally relevant animal model of human glioma. All cases were morphologically reclassified according to a new schema devised by the entire board, yielding a majority opinion diagnosis of astrocytoma (43, 22.3%), 19 of which were low-grade and 24 high-grade, and oligodendroglioma (134, 69.4%), 35 of which were low-grade and 99 were high-grade. Sixteen cases (8.3%) could not be classified as oligodendroglioma or astrocytoma based on morphology alone and were designated as undefined gliomas. The simplified classification scheme proposed herein provides a tractable means for future addition of molecular data, and also serves to highlight histologic similarities and differences between human and canine glioma.