New hypoglycemic constituents in ''gymnemic acid'' from Gymnema sylvestre
New hypoglycemic constituents in ''gymnemic acid'' from Gymnema sylvestre
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DOI：
10.1248/cpb.44.469
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发表时间：
1996-02-01
影响因子：
1.7
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Murakami, N;Murakami, T;Yoshikawa, M
对来自“匙羹藤酸”（G. sylvestre 的粗皂苷部分）的主要皂苷成分的降血糖活性的研究，不仅发现了两种新的皂苷：匙羹藤苷 a (1) 和 b (2)，而且还发现了匙羹藤苷 b 和匙羹藤酸 V (7) 作为活性成分。此外，发现1和2中连接16-或22-羟基的乙酰基很容易迁移到伯28-羟基，而很少观察到3中酰基从28-羟基迁移。
Investigation of hypoglycemic activity of major saponin constituents from ''gymnemic acid'', a crude saponin fraction of G. sylvestre, exposed not only two new saponins, gymnemosides a (1) and b (2), but also gymnemoside b and gymnemic acid V (7) as active principles. Furthermore, an acetyl group linked 16- or 22-hydroxy group in 1 and 2 was found to migrate easily to primary 28-hydroxyl group, while acyl migration from 28-hydroxy group in 3 was little observed.