Antihypertensive, cardio- and neuro-protective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats
Antihypertensive, cardio- and neuro-protective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats
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DOI：
10.1371/journal.pone.0233788
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发表时间：
2020-05-29
期刊：
影响因子：
3.7
通讯作者：
Dreassi, Elena
中科院分区：
文献类型：
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作者：
Pessina, Federica;Frosini, Maria;Dreassi, Elena
在高血压前期，适度控制血压（BP）可以通过营养方法获得。在自发性高血压大鼠（SHR）和年龄匹配的血压正常的Wistar京都品系中研究了富含具有ACE抑制活性的黄粉虫（鞘翅目：拟步甲科）（TM）脱脂幼虫的饮食的影响。用补充或不补充TM或卡托普利的标准实验室啮齿动物饲料喂养这些动物4周。在SHR中，TM饮食导致血压、心率和冠状动脉灌注压显著降低，以及红细胞谷胱甘肽/谷胱甘肽二硫化物比率增加。SHR大鼠脑片对氧化应激的抵抗力更强，含有较低水平的炎性细胞因子，而血管和肝酶活性不受影响。这些结果表明，TM可以被认为是一种新的功能性食品，可以降低体内血压，从而控制心血管相关的危险因素，如高血压。
In pre-hypertension, moderate control of blood pressure (BP) can be obtained by a nutritional approach. The effects of a diet enriched with defatted larvae of the mealworm Tenebrio molitor(Coleoptera: Tenebrionidae) (TM) endowed with ACE inhibitory activity was studied in both spontaneously hypertensive rats (SHR) and in the age-matched normotensive Wistar Kyoto strain. These were fed for 4 weeks with standard laboratory rodent chow supplemented with or without TM or captopril. In SHR, the TM diet caused a significant reduction in BP, heart rate and coronary perfusion pressure, as well as an increase in red blood cell glutathione/glutathione disulphide ratio. Rat brain slices of SHR were more resistant to oxidative stress and contained lower levels of inflammatory cytokines, while vascular and liver enzyme-activities were not affected. These results suggest that TM can be considered a new functional food that can lower BP in vivo and thus control cardiovascular-associated risk factors such as hypertension.