Injections of dopaminergic, cholinergic, serotoninergic and gabaergic drugs into the nucleus accumbens: effects on locomotor activity in the rat
Injections of dopaminergic, cholinergic, serotoninergic and gabaergic drugs into the nucleus accumbens: effects on locomotor activity in the rat
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伏隔核注射多巴胺能、胆碱能、血清素能和伽巴能药物：对大鼠运动活动的影响
DOI：
10.1016/0028-3908(81)90038-1
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发表时间：
1981
影响因子：
4.7
通讯作者：
Michael Wu
中科院分区：
文献类型：
--
作者：
Douglas L. Jones;G. Mogenson;Michael Wu
自发活动是通过向慢性插管大鼠的延髓核注射多巴胺引起的。还将多巴胺与胆碱能、胆碱能和GABA能激动剂和拮抗剂一起注射，以研究这些假定的神经递质对运动活性的可能贡献。卡巴胆碱引起多巴胺刺激活性的瞬时增强。阿托品减弱卡巴胆碱刺激的增强，但不减弱多巴胺刺激的活动。血清素减弱多巴胺刺激的活性。外周血清素拮抗剂，麦角新碱，也衰减运动。GABA的管理引起的双峰反应的运动，较低的剂量引起运动的小增加和较大的剂量引起减少。GABA拮抗剂印防己毒素在所有剂量下仅引起运动增加。这些结果表明，有没有一个胆碱能中间神经元的多巴胺刺激的途径subserving运动，但胆碱能和胆碱能的预测可能会调节自发活动。此外，他们认为，这种调制必须至少有一个抑制性中间神经元远离运动通路上的多巴胺突触。此外，这些结果表明，GABA能中间神经元的直接影响的途径subserving运动活动内的延髓核。
Locomotor activity was elicited by injecting dopamine into the nucleus accumbens of the chronically cannulated rat. Dopamine was also injected together with cholinergic, serotoninergic and GABAergic agonists and antagonists to investigate the possible contribution to locomotor activity of these putative neurotransmitters. Carbachol elicited a transient enhancement of dopamine-stimulated activity. Atropine attenuated carbachol-stimulated enhancement but did not attenuate dopamine-stimulated activity. Serotonin attenuated dopamine-stimulated activity. The peripheral serotonin antagonist, methysergide, also attenuated locomotion. The administration of GABA elicited a bimodal response in locomotion, the lower dose eliciting a small increase in locomotion and the larger dose eliciting a reduction. The GABA antagonist, picrotoxin, elicited only increases in locomotion at all doses. These results suggest that there is not a cholinergic interneuron on the dopamine-stimulated pathway subserving locomotion but that both cholinergic and serotoninergic projections may modulate locomotor activity. Further they suggest that such modulation must be at least one inhibitory interneuron away from the dopamine synapse on the locomotor pathway. In addition, these results suggest a direct influence of GABAergic interneurons on the pathway subserving locomotor activity within the nucleus accumbens.