Electromyography as a recording system for eyeblink conditioning with functional magnetic resonance imaging
Electromyography as a recording system for eyeblink conditioning with functional magnetic resonance imaging
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DOI：
10.1006/nimg.2002.1199
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发表时间：
2002-10-01
期刊：
影响因子：
5.7
通讯作者：
Disterhoft, JF
中科院分区：
文献类型：
--
作者：
Knuttinen, MG;Parrish, TB;Disterhoft, JF
本研究旨在开发一种在进行功能磁共振成像（fMRI）时记录眨眼反应的合适方法。考虑到磁铁外行为设置的复杂性，本研究试图调整并进一步优化一种适合进行事件相关fMRI实验的眨眼条件反射方法。该方法包括从右眼眼轮匝肌获取肌电图信号，随后将其放大并转换为头部线圈外的光信号。这种光信号在离开磁室后又被转换回电信号。使用肌电图（EMG）检测眨眼来测量延迟眨眼条件反射范式的反应。结果表明：(1)肌电图是fMRI检测眨眼的灵敏方法；(2)磁共振脉冲序列产生了最小的肌电信号相互作用或伪影；(3)磁共振图像未检测到肌电相关伪影。此外，对功能数据的分析显示，激活区域之前已在人类眨眼条件反射的正电子发射断层扫描研究中显示。我们的结果支持这种行为设置作为与功能磁共振成像相结合的合适方法的强度。(C) 2002 Elsevier Science （USA）。
This study was designed to develop a suitable method of recording eyeblink responses while conducting functional magnetic resonance imaging (fMRI). Given the complexity of this behavioral setup outside of the magnet, this study sought to adapt and further optimize an approach to eyeblink conditioning that would be suitable for conducting event-related fMRI experiments. This method involved the acquisition of electromyographic (EMG) signals from the orbicularis oculi of the right eye, which were subsequently amplified and converted into an optical signal outside of the head coil. This optical signal was converted back into an electrical signal once outside the magnet room. Electromyography (EMG)-detected eyeblinks were used to measure responses in a delay eyeblink conditioning paradigm. Our results indicate that: (1) electromyography is a sensitive method for the detection of eyeblinks during fMRI; (2) minimal interactions or artifacts of the EMG signal were created from the magnetic resonance pulse sequence; and (3) no electromyography-related artifacts were detected in the magnetic resonance images. Furthermore, an analysis of the functional data showed areas of activation that have previously been shown in positron emission tomography studies of human eyeblink conditioning. Our results support the strength of this behavioral setup as a suitable method to be used in association with fMRI. (C) 2002 Elsevier Science (USA).