Gastric emptying time in patients with primary hypothyroidism
Gastric emptying time in patients with primary hypothyroidism
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DOI：
10.1097/00042737-199709000-00014
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发表时间：
1997-09-01
影响因子：
2.1
通讯作者：
Tanyeri, F
中科院分区：
文献类型：
--
作者：
Kahraman, H;Kaya, N;Tanyeri, F
背景和目标：由于胃肠动力减慢而引起的症状是大多数原发性甲状腺功能减退症患者的重要问题。本研究的目的是计算胃排空时间与原发性甲状腺功能减退症患者使用放射性同位素methods.Patients和方法：15甲状腺功能减退症患者（2男，13女）参加了这项研究。平均年龄为43岁（范围38-50岁）。只有最近被诊断并且之前没有接受过治疗的患者才被纳入研究。对上消化道进行放射学和内窥镜检查。排除胃出口梗阻患者。12名健康和甲状腺功能正常的人没有检测到胃肠道病变作为对照组进行了检查。该组的平均年龄为45岁（范围35-55）。患者和对照组接受半固体餐含有1 mCi锝-99 m硫胶体和测量从epigastrium.Results：平均胃排空半衰期（t（一半））为112.13 +/- 48.96分钟，甲状腺功能减退症患者和57.87 +/- 6.38分钟，在对照组。甲减组胃排空时间与对照组比较有显著性差异（P< 0.001）。胃排空时间与血清促甲状腺激素（TSH）水平无相关性。结论：放射性同位素研究是一种安全、快速、可靠的测定原发性甲状腺功能减退症患者胃排空时间的方法。
Background and objectives: Symptoms due to slowing of gastrointestinal motility constitute an important problem in most patients with primary hypothyroidism. The purpose of this study was to calculate gastric emptying time in patients with primary hypothyroidism using a radioisotopic method.Patients and methods: Fifteen hypothyroid patients (2 male, 13 female) participated in the study. Mean age was 43 (range 38-50) years. Only patients who had been recently diagnosed and had received no previous therapy were included in the study. Radiological and endoscopic examination of the upper gastrointestinal tract was carried out. Patients with gastric outlet obstruction were excluded. Twelve healthy and euthyroid people with no detectable gastrointestinal pathology were examined as a control group. The mean age of this group was 45 (range 35-55) years. Patients and control group received a semisolid meal containing 1 mCi technetium-99m sulphur colloid and measurements were made from the epigastrium.Results: Mean gastric emptying half-time (t(half)) was 112.13 +/- 48.96 min in hypothyroid patients and 57.87 +/- 6.38 min in the control group. Gastric emptying time of the hypothyroid patients was significantly different from the control group ( P< 0.001). There was no correlation between gastric emptying time and serum thyroid-stimulating hormone (TSH) levels.Conclusion: We concluded that radioisotopic study is a safe, rapid and reliable method for determining gastric emptying time in patients with primary hypothyroidism.