SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME
SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME
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DOI：
10.1038/290457a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
YOUNG, IG
中科院分区：
文献类型：
--
作者：
ANDERSON, S;BANKIER, AT;YOUNG, IG
人类线粒体基因组16569个碱基对的完整序列。定位了12S和16S rRNA、22tRNA、细胞色素c氧化酶亚基I、II和III、atp酶亚基6、细胞色素b等8个预测蛋白编码基因。该序列显示出极端的经济性，因为基因之间没有或只有少数非编码碱基，并且在许多情况下，终止密码子不编码在DNA中，而是在转录后通过mRNA的聚腺苷化产生的。
The complete sequence of the 16,569 base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNA, 22tRNA, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and 8 other predicted protein coding genes were located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNA.