Alterations of Hematological Variations in Rats Exposed to Extremely Low Frequency Magnetic Fields (50Hz)
Alterations of Hematological Variations in Rats Exposed to Extremely Low Frequency Magnetic Fields (50Hz)
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DOI：
10.1016/j.arcmed.2009.07.001
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发表时间：
2009-07-01
影响因子：
7.7
通讯作者：
Mete, Nuriye
中科院分区：
文献类型：
--
作者：
Cakir, Dilek Ulker;Yokus, Beran;Mete, Nuriye
背景和目标。本研究的目的是评估极低频电磁场（ELF-EMF）对大鼠全血参数（血液学参数）的可能影响。将2004年从土耳其Dicle大学医学科学应用和研究中心获得的48只雌性Wistar大鼠分为4个单独的组：两个暴露组（0.97 mT，50和100天，3 h/天）和两个对照组（假手术）。暴露于电磁场50天的大鼠中嗜酸性粒细胞、血红蛋白和MPV水平显著降低。比较暴露50天和100天的大鼠数据发现，暴露100天的大鼠MPV水平显著降低，暴露组与假暴露组之间的总白细胞、血小板、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞计数以及红细胞、Hct、MCH、MCHC、RDW、PLT和PDW水平均无显著差异。ELF-EMF暴露对体重没有影响。此外，肝脏重量在组间未显示任何显著差异。我们的研究结果表明，所施加的ELF-EMF暴露可能会引起轻微的，但在生理范围内的大鼠的一些血液学参数的统计学显着的改变。(C)2009年墨西哥社会保障局。爱思唯尔公司出版
Background and Aims. The aim of this study was to evaluate the possible effects of in vivo exposure to extremely low frequency electromagnetic fields (ELF-EMF) on whole blood parameters (hematological parameters) in rats.Methods. Forty eight female Wistar rats, obtained from the Medical Science Application and Research Center, Dicle University, Turkey in 2004 were divided into four separate groups: two exposed groups (0.97 mT, 50 and 100 days, 3 h/day) and two controls (sham).Results. Eosinophil, hemoglobin and MPV levels significantly decreased in rats that were exposed to EMF for 50 days. When the data for rats exposed for 50 days and 100 days were compared, it was found that MPV levels in rats exposed for 100 days were significantly lower.There was no significant difference in total leukocyte, neutrofil, lymphocyte, monocyte, eosinophil and basophil counts, or in erythrocyte, Hct, MCH, MCHC, RDW, PLT and PDW levels between the exposed and sham-exposed groups. ELF-EMF exposure had no effect on body weight. Also, liver weight did not show any significant difference between groups.Conclusions. Our results indicate that the applied ELF-EMF exposure may induce slight but statistically significant alterations in some hematological parameters of rats, within the physiological range. (C) 2009 IMSS. Published by Elsevier Inc.