Comparison between Betamethasone, Fluorometholone and Loteprednol Etabonate on intraocular pressure in patients after keratorefractive surgery
Comparison between Betamethasone, Fluorometholone and Loteprednol Etabonate on intraocular pressure in patients after keratorefractive surgery
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DOI：
10.1016/j.joco.2017.11.008
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发表时间：
2018-06-01
影响因子：
1.5
通讯作者：
Rajaee, Parisa
中科院分区：
文献类型：
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作者：
Shokoohi-Rad, Saeed;Daneshvar, Ramin;Rajaee, Parisa
目的：本研究的目的是比较市售倍他米松、伊朗氟米龙和氯替泼诺对接受角膜屈光手术的患者的高眼压作用。在这项前瞻性随机临床试验中，纳入了150例患者的300只眼，患者被随机分配到3组，并使用3种类固醇滴剂中的一种（倍他米松0.1%、氟米龙0.1%和氯替泼诺0.5%）。术后2、4和6周测量眼内压（IOP）。结果：150例300眼术后6周眼压≥ 22mmHg者，氟米龙组2眼（2%），倍他米松组12眼（12%），氯替泼诺组16眼（16%）。方差分析（ANOVA）结果显示，术后2、4天组间眼压升高差异有统计学意义（P
Purpose: The aim of this study was to compare the ocular hypertensive effect of the commercially available Betamethasone, Fluorometholone in Iran and Loteprednol Etabonate in patients undergoing keratorefractive surgery.Methods: In this prospective randomized clinical trial, 300 eyes of 150 patients were included, and patients were randomly assigned to 3 groups and used one of the 3 steroid drops (Betamethasone 0.1%, Fluorometholone 0.1%, and Loteprednol Etabonate 0.5%) after myopic photorefractive keratectomy (PRK). Intraocular pressure (IOP) was measured 2, 4, and 6 weeks post-surgery. Twenty-two mmHg was set as the threshold IOP for starting anti-glaucoma medication and tapering steroid drops.Results: Of 300 eyes from 150 patients over the first 6 postoperative weeks, 2 eyes in Fluorometholone group (2%), 12 eyes in Betamethasone group (12%), and 16 eyes in Loteprednol group (16%) had IOP equal or more than 22 mmHg. Analysis of variance (ANOVA) test showed that the rise in IOP was significantly different between groups in the 2nd and 4th (P