THE GLABROUS EPIDERMIS OF CAVIES CONTAINS A POWERFUL BATTERY
THE GLABROUS EPIDERMIS OF CAVIES CONTAINS A POWERFUL BATTERY
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DOI：
10.1152/ajpregu.1982.242.3.r358
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
VANABLE, JW
中科院分区：
文献类型：
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作者：
BARKER, AT;JAFFE, LF;VANABLE, JW
豚鼠皮肤上各种无毛（和无腺体）区域的电压范围为30-100 mV，内部为正;有毛区域为0-10 mV。[多毛区域也倾向于维持较低的经皮电压。]当在豚鼠无毛的表皮上做一个切口时，切口边缘的每一毫米都有一微安的电流流过。这些伤口电流产生横向的表皮内电压梯度或λ场。切口附近的电场为100-200 mV/mm;电场随着距离切口的距离而下降，空间常数为0.3-0.4 mm。切口附近的表皮驱动高达300 μ A/cm 2穿过其自身;这些电流和电势可以被阿米洛利显著、快速和（在某种程度上）可逆地降低。海鞘的毛发和无腺体的皮肤具有与青蛙相当的能量和特性的电池;这种哺乳动物电池可能主要有助于表皮伤口愈合，而不是盐的吸收。
Voltages across various glabrous (and gland-free) regions of cavy skin range from 30-100 mV, inside positive; across hairy ones, 0-10 mV. [Hairy areas also tend to maintain lower transcutaneous voltages in man.] When an incision is made through the glabrous epidermis of the cavy, a microampere flows through each millimeter of the cut''s edge. These wound currents generate lateral, intraepidermal voltage gradients or fields of .apprx. 100-200 mV/mm near the cut; fields which decline with distance from the cut with a space constant of 0.3-0.4 mm. The epidermis near a cut drives up to 300 .mu.A/cm2 across itself; these currents and potentials can be grossly, rapidly and (to some extent) reversibly reduced by amiloride. The hair and gland-free skin of cavies has a battery comparable in power and character to that of frogs; this mammalian battery may primarily subserve epidermal wound healing rather than salt uptake.