Bone marrow contribution to skeletal muscle: A physiological response to stress
Bone marrow contribution to skeletal muscle: A physiological response to stress
复制标题
DOI：
10.1016/j.ydbio.2004.12.024
复制
发表时间：
2005-03-15
影响因子：
2.7
通讯作者：
Blau, HM
中科院分区：
文献类型：
--
作者：
Palermo, AT;LaBarge, MA;Blau, HM
成体骨髓干细胞 (BMDC) 已被证明在移植到新宿主后可生成多种组织。然而，这些细胞的参与是否是对损伤的正常反应的一部分仍然存在争议。使用一对联体连接的基因标记小鼠和野生型小鼠，我们在此表明，辐射引起的靶组织损伤、骨髓注射到循环中以及骨髓移植后果的免疫扰动对于骨髓对肌纤维的贡献来说并不是必需的。此外，严重的毒素引起的损伤并不是先决条件，因为 BMDC 对肌肉的贡献会随着肌肉超负荷或强迫运动导致的肌肉活动增加而增强。事实上，这两种形式的肌肉压力（1 个月内）比自愿跑步（6 个月内）产生更快的贡献。这些结果表明，BMDC 有助于肌纤维响应健康有机体一生中遇到的生理压力。 (C) 2005 Elsevier Inc. 保留所有权利。
Adult bone marrow-derived stem cells (BMDC) have been shown to contribute to numerous tissues after transplantation into a new host. However, whether the participation of these cells is part of the normal response to injury remains a matter of debate. Using parabiotically joined pairs of genetically labeled and wildtype mice, we show here that irradiation-induced damage of the target tissue, injection of bone marrow into the circulation, and immunological perturbation that are consequences of bone marrow transplantation are not necessary for bone marrow contribution to myofibers. Moreover, severe toxin-induced damage is not a prerequisite, as BMDC contribution to muscle is enhanced in response to increased muscle activity resulting from muscle overloading or forced exercise. Indeed, these two forms of muscle stress result in much more rapid contribution (within 1 month) than Voluntary running (6 months). These results indicate that BMDC contribute to myofibers in response to physiologic stresses encountered by healthy organisms throughout life. (C) 2005 Elsevier Inc. All rights reserved.