Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects
Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects
复制标题
DOI：
10.3928/23258160-20150909-03
复制
发表时间：
2015-09-01
影响因子：
1
通讯作者：
Kashani, Amir H.
中科院分区：
文献类型：
--
作者：
Matsunaga, Douglas R.;Yi, Jack J.;Kashani, Amir H.
背景和目的：光学相干断层扫描血管造影（OCTA）是一种新型、非侵入性OCT技术，能够对视网膜血管系统进行成像。本研究旨在通过 OCTA 评估糖尿病人类受试者的视网膜微血管系统并评估潜在的临床应用。 患者和方法：对 33 名糖尿病视网膜病变受试者进行横断面研究。使用扫频 OCTA 原型和基于相位和强度的对比算法在 3 mm x 3 mm 切片上进行 OCTA。通过相应的临床检查和荧光素血管造影（如果有）对 OCT 血管造影进行研究，以评估准确性和临床实用性。 结果：OCTA 能够证明糖尿病视网膜病变受试者的大多数临床相关血管变化，包括微动脉瘤、血管灌注受损、某些形式的视网膜内液体、血管袢、视网膜内微血管异常、 新生血管形成和棉毛斑与荧光素血管造影基本一致。结论：OCTA 生成高分辨率血管造影照片，说明糖尿病视网膜病变的许多临床相关发现，并为荧光素血管造影提供新的补充或替代方案。尽管目前是一项研究技术，但 OCTA 与标准 OCT 成像相结合在评估糖尿病视网膜病变黄斑并发症方面至少与荧光素血管造影一样好。
BACKGROUND AND OBJECTIVE: Optical coherence tomography angiography (OCTA) is a novel, non-invasive OCT technique capable of imaging the retinal vasculature. This study aims to evaluate the retinal microvasculature in diabetic human subjects with OCTA and assess potential clinical applications.PATIENTS AND METHODS: Cross-sectional study of 33 subjects with diabetic retinopathy. OCTA was performed on 3 mm x 3 mm sections using a sweptsource OCTA prototype and a phase-and intensity-based contrasting algorithm. OCT angiograms were studied with corresponding clinical examination and fluorescein angiograms, when available, to assess accuracy and clinical utility.RESULTS: OCTA was able to demonstrate most clinically relevant vascular changes in subjects with diabetic retinopathy, including microaneurysms, impaired vascular perfusion, some forms of intraretinal fluid, vascular loops, intraretinal microvascular abnormalities, neovascularization, and cotton-wool spots that were largely consistent with fluorescein angiography.CONCLUSION: OCTA generates high-resolution angiograms that illustrate many of the clinically relevant findings in diabetic retinopathy and offers a novel complement or alternative to fluorescein angiography. Although currently an investigational technique, OCTA in combination with standard OCT imaging is at least as good as fluorescein angiography in the evaluation of the macular complications of diabetic retinopathy.