Chest CT findings related to mortality of patients with COVID-19: A retrospective case-series study
Chest CT findings related to mortality of patients with COVID-19: A retrospective case-series study
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DOI：
10.1371/journal.pone.0237302
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发表时间：
2020-08-25
期刊：
影响因子：
3.7
通讯作者：
Xia, Liming
中科院分区：
文献类型：
--
作者：
Hu, Yiqi;Zhan, Chenao;Xia, Liming
随着当前新冠肺炎疫情在中国以外的全球150多个国家蔓延，死亡人数不断增加，需要对死亡病例的临床数据和影像学表现进行探索，以便更多的医生、放射科医生和研究人员获得重要信息，拯救更多的生命。方法回顾性分析73例COVID-19死亡患者的资料。从电子病历中提取患者的临床和实验室资料。总结临床资料、炎症相关实验室结果及CT影像学表现。分析实验室结果及基于胸部CT的肺部受累影像特征及严重程度评分的动态变化。结果患者平均年龄67±12岁。典型临床症状为发热（88%）、咳嗽（62%）、呼吸困难（23%）。65%的患者至少有一种基础疾病。GGO伴实变是5个肺叶中最常见的特征（占各肺叶的47%-53%），两肺的总严重程度评分为12.97 +/- 5.87。随访胸部CT与初始CT相比，GGO合并实变的比例明显增加，平均CT总评分(14.53 +/- 5.76 vs. 6.60 +/- 5.65
Background As the current outbreak of COVID-2019 disease has spread to the other more than 150 countries besides China around the world and the death number constantly increased, the clinical data and radiological findings of death cases need to be explored so that more physicians, radiologists and researchers can gain important information to save more lives. Methods 73 patients who died from COVID-19 were retrospectively included. The clinical and laboratory data of the patients were extracted from electronic medical records. The clinical data, inflammation-related laboratory results, and CT imaging features were summarized. The laboratory results and dynamic changes of imaging features and severity scores of lung involvement based on chest CT were analyzed. Results The mean age was 67 +/- 12 years. The typical clinical symptoms included fever (88%), cough (62%) and dyspnea (23%). 65% patients had at least one underlying disease. GGO with consolidation was the most common feature for the five lung lobes (47%-53% among the various lobes), with total severity score of 12.97 +/- 5.87 for the both lungs. The proportion of GGO with consolidation is markedly increased on follow-up chest CT compared with initial CT scans, as well as the averaging total CT scores (14.53 +/- 5.76 vs. 6.60 +/- 5.65; P