Occupational and environmental risk factors for idiopathic pulmonary fibrosis: A multicenter case-control study
Occupational and environmental risk factors for idiopathic pulmonary fibrosis: A multicenter case-control study
复制标题
DOI：
10.1093/aje/152.4.307
复制
发表时间：
2000-08-15
影响因子：
5
通讯作者：
Waldron, JA
中科院分区：
文献类型：
--
作者：
Baumgartner, KB;Samet, JM;Waldron, JA
在一项多中心病例对照研究中，对临床和组织学诊断的特发性肺纤维化（IPF）（一种病因不明的慢性弥漫性间质性肺病）进行了职业暴露调查。结果基于 1989 年 1 月至 1993 年 7 月期间在 16 个转诊中心诊断的 248 例年龄 20-75 岁的病例。通过随机数字拨号确定了 491 名对照者，并与性别、年龄和地理区域的病例相匹配。使用标准电话问卷收集数据。职业因素基于持续 6 个月或以上的详细工作历史以及工作活动、爱好和特定物质清单。在条件多变量逻辑回归分析中根据年龄和吸烟进行调整后，一些职业因素与 IPF 显着相关：农业（比值比 (OR) = 1.6，95% 置信区间 (CI)：1.0，2.5）；牲畜（OR = 2.7，95% CI：1.3，5.5）；美发（OR = 4.4，95% CI：1.2，16.3），金属粉尘（OR = 2.0，95% CI：1.0，4.0）；饲养鸟类（OR = 4.7，95% CI：1.6，14.1）；石材切割/抛光（OR = 3.9，95% CI：1.2，12.7）；和蔬菜灰尘/动物灰尘（OR = 4.7，95% CI：2.1，10.4）。检测到吸烟与接触牲畜（p = 0.06）和农业（p = 0.08）之间存在相互作用。结果证实了之前的研究表明，多尘环境会增加风险。
Occupational exposures were investigated in a multicenter case-control study of clinically and histologically diagnosed idiopathic pulmonary fibrosis (IPF), a chronic diffuse interstitial lung disease of unknown etiology. Results are based on 248 cases, aged 20-75 years, diagnosed at 16 referral centers between January 1989 and July 1993. There were 491 controls ascertained by random digit dialing and matched to cases on sex, age, and geographic region. Data were collected using a standard telephone questionnaire. Occupational factors were based on a detailed history of jobs lasting 6 months or more and job activity, hobby, and specific substance checklists. Several occupational factors, adjusted for age and smoking in conditional multivariate logistic regression analyses, were significantly associated with IPF: farming (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5); livestock (OR = 2.7, 95% CI: 1.3, 5.5); hairdressing (OR = 4.4, 95% CI: 1.2, 16.3), metal dust (OR = 2.0, 95% CI: 1.0, 4.0); raising birds (OR = 4.7, 95% CI: 1.6, 14.1); stone cutting/polishing (OR = 3.9, 95% CI: 1.2, 12.7); and vegetable dust/animal dust (OR = 4.7, 95% CI: 2.1, 10.4). Interaction was detected between smoking and exposure to livestock (p = 0.06) and farming (p = 0.08). Results confirm previous studies showing increased risk associated with dusty environments.