ROLE OF PLATELETS IN TUMOR-CELL METASTASES
ROLE OF PLATELETS IN TUMOR-CELL METASTASES
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DOI：
10.7326/0003-4819-95-5-636
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发表时间：
1981-01-01
影响因子：
39.2
通讯作者：
PEARLSTEIN, E
中科院分区：
文献类型：
--
作者：
KARPATKIN, S;PEARLSTEIN, E
血小板可能在动物肿瘤转移的发生中起作用。体内超微结构研究显示，肿瘤栓子受阻，周围有血小板。几种肿瘤细胞系在体内可引起血小板减少。某些肿瘤细胞在体外聚集血小板。某些肿瘤细胞在体外聚集血小板的能力与它们在体内的转移潜能之间存在相关性。抗血小板药物已经损害或改变了某些肿瘤转移的扩散。血小板可能在肿瘤细胞通过血管内皮细胞屏障的隔离、黏附和穿透中发挥作用，阻止它们迅速从循环中清除，并允许血管外形成细胞巢。抗血小板药物，特别是前列腺素，如果在接种肿瘤细胞之前给药，可能会证明在防止实验性动物转移方面是有用的。当患者出现已确定的肿瘤时，它们在人类恶性肿瘤中的潜力仍有待确定。
Platelets may have a role in the development of animal tumor metastases. Ultrastructural studies in vivo have shown arrested tumor emboli surrounded by platelets. Several tumor cell lines induce thrombocytopenia in vivo. Certain tumor cells aggregate platelets in vitro. Correlations exist between the ability of some tumor cells to aggregate platelets in vitro and their metastatic potential in vivo. Antiplatelet agents have impaired or altered the spread of certain tumor metastases. Platelets may have a role in the sequestration, adherence and penetration of tumor cells through the blood vessel endothelial cell barrier, preventing their rapid clearance from the circulation and allowing extravascular formation of nests of cells. Antiplatelet agents, particularly prostaglandins, may prove useful in preventing experimental animal metastases when administered before the inoculation of tumor cells. Their potential in human malignancy when the patient presents with an established tumor remains to be established.