Rhodium-catalyzed asymmetric synthesis of indanones: development of a new "axially chiral" bisphosphine ligand.
Rhodium-catalyzed asymmetric synthesis of indanones: development of a new "axially chiral" bisphosphine ligand.
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DOI：
10.1002/chin.200629083
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发表时间：
2006-02
影响因子：
15
通讯作者：
R. Shintani;Keiji Yashio;Tomoaki Nakamura;K. Okamoto;Toyoshi Shimada;Tamio Hayashi
中科院分区：
文献类型：
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作者：
R. Shintani;Keiji Yashio;Tomoaki Nakamura;K. Okamoto;Toyoshi Shimada;Tamio Hayashi
研究了铑催化的α-芳基炔丙醇不对称异构化反应。利用新开发的轴向手性双膦配体实现了高的对映选择性。该配体是独特的，因为在与过渡金属络合时，由于同一分子内存在其他手性轴，其轴向手性被固定为单一构型。
A rhodium-catalyzed asymmetric isomerization of racemic alpha-arylpropargyl alcohols to beta-chiral indanones has been developed. High enantioselectivity has been realized by the use of a newly developed axially chiral bisphosphine ligand. This ligand is unique in the sense that its axial chirality is fixed to a single configuration upon complexation to a transition metal due to other chiral axes existing within the same molecule.