New genetic approaches shed light on TB virulence.
New genetic approaches shed light on TB virulence.
复制标题
新的遗传学方法揭示了结核病的毒力。
DOI：
10.1016/j.tim.2005.06.003
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Rubin,EricJ
中科院分区：
文献类型：
--
作者：
Murry,JeffreyP;Rubin,EricJ
Although tuberculosis has been studied for more than a century, insights into the molecular mechanisms by which it causes disease remain fairly limited. The current genetic boom in this system promises to reveal new virulence mechanisms, making this an exciting time to be studying this disease. Long considered a technical ‘poor relation', tuberculosis research has developed into a source for creative techniques and ideas. In the midst of this development, it is important to keep in mind the limitations of each new approach that is employed to study this organism. This review examines the genetic approaches that are currently being used to study tuberculosis, with an emphasis on new developments that promise to improve our understanding of the pathogenic mechanisms ofMycobacterium tuberculosis.
