QUANTITATIVE MUSCLE ULTRASOUND AND QUADRICEPS STRENGTH IN PATIENTS WITH POST-POLIO SYNDROME
QUANTITATIVE MUSCLE ULTRASOUND AND QUADRICEPS STRENGTH IN PATIENTS WITH POST-POLIO SYNDROME
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DOI：
10.1002/mus.24272
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发表时间：
2015-01-01
期刊：
影响因子：
3.4
通讯作者：
van Dijk, Johannes P.
中科院分区：
文献类型：
--
作者：
Bickerstaffe, Alice;Beelen, Anita;van Dijk, Johannes P.
简介：我们研究了肌肉超声是否可以区分受脊髓灰质炎后综合征（PPS）影响的肌肉和健康肌肉，以及超声异常的严重程度是否与肌肉力量有关。研究方法：对48例PPS患者和12例健康对照者的股四头肌回声强度、肌肉厚度和等长肌力进行了测量。结果：PPS患者的回声强度明显高于健康对照组，肌肉厚度明显低于健康对照组。在患者中，回声强度和肌肉厚度与肌肉力量独立相关。回声强度和肌肉厚度的联合测量与肌肉力量的相关性比单独的参数更强。结论：定量超声将健康肌肉与受PPS影响的肌肉区分开来，肌肉质量和数量的测量与肌肉力量有关。因此，超声可能是评估疾病严重程度和监测PPS患者疾病进展或临床干预引起的变化的有用工具。
Introduction: We investigated whether muscle ultrasound can distinguish muscles affected by post-polio syndrome (PPS) from healthy muscles and whether severity of ultrasound abnormalities is associated with muscle strength. Methods: Echo intensity, muscle thickness, and isometric strength of the quadriceps muscles were measured in 48 patients with PPS and 12 healthy controls. Results: Patients with PPS had significantly higher echo intensity and lower muscle thickness than healthy controls. In patients, both echo intensity and muscle thickness were associated independently with muscle strength. A combined measure of echo intensity and muscle thickness was more strongly related to muscle strength than either parameter alone. Conclusions: Quantitative ultrasound distinguishes healthy muscles from those affected by PPS, and measures of muscle quality and quantity are associated with muscle strength. Hence, ultrasound could be a useful tool for assessing disease severity and monitoring changes resulting from disease progression or clinical intervention in patients with PPS.