SAS amplification in soft tissue sarcomas.
SAS amplification in soft tissue sarcomas.
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DOI：
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发表时间：
1992-07
期刊：
影响因子：
11.2
通讯作者：
Sharon Smith;S. Weiss;S. A. Jankowski;M. Coccia;P. Meltzer
中科院分区：
文献类型：
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作者：
Sharon Smith;S. Weiss;S. A. Jankowski;M. Coccia;P. Meltzer
基因扩增是许多人实体瘤中基因表达增加的重要机制。我们最近发现并克隆了恶性纤维组织细胞瘤中一种新的DNA扩增单位的序列。扩增的序列来源于染色体12 q13 -14，编码一种称为SAS（肉瘤扩增序列）的基因。在本研究中，研究了一系列软组织肉瘤，以进一步表征SAS扩增现象。22例恶性纤维组织细胞瘤和3例脂肪肉瘤中有7例（32%）含有SAS扩增。引人注目的是，所有具有SAS扩增的肿瘤都发生在中心部位（即，在腹部或腹股沟区域）而不是在四肢（即，在腿的手臂）。这些观察结果表明，SAS扩增发生在间充质肿瘤的显着频率，特别是与腹部疾病。
Gene amplification is an important mechanism of increased gene expression in a number of human solid tumors. We have recently identified and cloned sequences from a novel DNA amplification unit in malignant fibrous histiocytoma. The amplified sequences are derived from chromosome 12q13-14 and encode a gene designated SAS (sarcoma amplified sequence). In the present study, a series of soft tissue sarcomas was studied to characterize further the phenomenon of SAS amplification. Seven of 22 (32%) malignant fibrous histiocytomas and three liposarcomas contained SAS amplification. Strikingly, all of the tumors with SAS amplification occurred in central sites (i.e., in the abdominal or inguinal regions) rather than in the extremities (i.e., in the arms of legs). These observations demonstrate that SAS amplification occurs with a significant frequency in mesenchymal tumors and is particularly associated with abdominal disease.