Sleep Deprivation and Late Bedtime Impair Sperm Health Through Increasing Antisperm Antibody Production: A Prospective Study of 981 Healthy Men.
Sleep Deprivation and Late Bedtime Impair Sperm Health Through Increasing Antisperm Antibody Production: A Prospective Study of 981 Healthy Men.
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DOI：
10.12659/msm.900101
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发表时间：
2017-04-16
期刊：
影响因子：
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通讯作者：
Yu CH
中科院分区：
文献类型：
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作者：
Liu MM;Liu L;Chen L;Yin XJ;Liu H;Zhang YH;Li PL;Wang S;Li XX;Yu CH
本研究旨在探讨睡眠时间和就寝时间对精子健康的影响及其可能的机制。我们将981名中国健康男性根据研究设定的就寝时间（A=晚上8-10点，B=晚上10点后，C=午夜后）和睡眠时间随机分为三组：第一组=<6.0小时（短），第二组=7.0-8.0小时（平均），第三组=>9.0小时（长）。根据睡眠模式检查精子形态、计数、存活率和活力。测定精液中抗精子抗体（阿萨）的产生。各组中短睡眠者精子计数及存活率均低于其他组（均P<0.01）。C1与A1、C2与A2、B2比较，差异均有统计学意义（P均<0.05或0.01）。短时间睡眠者精液活动率低于正常睡眠者和长时间睡眠者（均P<0.01）。C1与A1或B1之间的就寝时间相关结果差异有统计学意义（P<0.05或0.01）。另外，各组中短睡眠者ASA阳性参与者的比例和ASA表达人群的发生率均明显高于其他组（均P<0.05）。在研究队列中，睡眠时间长短和晚睡与精子健康受损有关，部分原因是增加了精液中的阿萨产量。
The aim of this study was to investigate the effects of sleep duration and bedtime on sperm health, and the possible mechanism involved. We randomly divided 981 healthy Chinese men into groups according to research-set bedtimes (A=8–10 PM, B=after 10 PM, and C=after midnight) and sleep durations: group 1=<6.0 h (short), group 2=7.0–8.0 h (average), and group 3=>9.0 h (long). Sperm morphology, count, survival, and motility were examined according to sleep patterns. Antisperm antibody (ASA) production in semen was determined. Sperm counts and their survival rates were lower in the short sleepers as compared to others within each group (all P<0.01). The lower counts and survival rates were observed in different bedtimes, with significant differences found between measurements of C1 vs. A1 and C2 vs. A2 or B2 (all P<0.05 or 0.01). Semen motility was lower in the short sleepers as compared to the average and long sleepers (all P<0.01). There were differences in the bedtime-related results between measurements of C1 vs. A1 or B1 (P<0.05 or 0.01). Additionally, the population proportion for the ASA-positive participates and incidence of the ASA-expressed population obviously increased in the short sleepers as compared to others within each group (all P<0.05). Short and long sleep durations and late bedtime were associated with impaired sperm health in the study cohort, partly through increasing ASA production in the semen.