Genomic Assemblies of Members of Burkholderia and Related Genera as a Resource for Natural Product Discovery.
Genomic Assemblies of Members of Burkholderia and Related Genera as a Resource for Natural Product Discovery.
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DOI：
10.1128/mra.00485-20
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发表时间：
2020-10-15
影响因子：
0.8
通讯作者：
Mahenthiralingam E
中科院分区：
文献类型：
--
作者：
Mullins AJ;Jones C;Bull MJ;Webster G;Parkhill J;Connor TR;Murray JAH;Challis GL;Mahenthiralingam E
从临床和环境来源分离的450个伯克霍尔德菌科成员的基因组被测序和组装，作为基因组挖掘的资源。对该集合的基因组分析使得能够鉴定多种代谢物及其生物合成基因簇，包括抗生素唐菖蒲素、icosalide A、enacloxin和cepacin A。从临床和环境来源分离的450个伯克霍尔德菌科成员的基因组被测序和组装，作为基因组挖掘的资源。对该集合的基因组分析使得能够鉴定多种代谢物及其生物合成基因簇，包括抗生素唐菖蒲素、icosalide A、enacloxin和cepacin A。
The genomes of 450 members of Burkholderiaceae, isolated from clinical and environmental sources, were sequenced and assembled as a resource for genome mining. Genomic analysis of the collection has enabled the identification of multiple metabolites and their biosynthetic gene clusters, including the antibiotics gladiolin, icosalide A, enacyloxin, and cepacin A. The genomes of 450 members of Burkholderiaceae, isolated from clinical and environmental sources, were sequenced and assembled as a resource for genome mining. Genomic analysis of the collection has enabled the identification of multiple metabolites and their biosynthetic gene clusters, including the antibiotics gladiolin, icosalide A, enacyloxin, and cepacin A.