In vitro and in vivo expression of Galα-(1,3)Gal on porcine islet cells is age dependent
In vitro and in vivo expression of Galα-(1,3)Gal on porcine islet cells is age dependent
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DOI：
10.1677/joe.0.1770127
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发表时间：
2003-04-01
影响因子：
4
通讯作者：
Korbutt, GS
中科院分区：
文献类型：
--
作者：
Rayat, GR;Rajotte, RV;Korbutt, GS
The expression of Galalpha-(1,3)Gal (alphaGal) on porcine islet cells remains controversial. Several groups have reported that porcine islet endocrine cells do not express alphaGal while we have shown in neonatal porcine islets (NPI) that beta cells do express this antigen. We hypothesize that endocrine cells expressing alphaGal on NPI are less mature cells that may have originated from ductal cells and that expression of this antigen disappears as they develop into fully mature beta cells. Thus, we further examined alphaGal expression on various porcine islet cell preparations and correlated this with the proportion of cytokeratin 7 (CK7)-positive ductal cells. hi vitro and in vivo expression of alphaGal and CK7 was significantly (P
