Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity
Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity
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DOI：
10.1038/mp.2015.185
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发表时间：
2016-10-01
影响因子：
11
通讯作者：
Du, C.
中科院分区：
文献类型：
--
作者：
Chen, W.;Liu, P.;Du, C.
可卡因影响神经元活动并收缩脑血管，使得难以确定可卡因诱导的脑血流量（CBF）变化是否反映神经元活化或其血管活性作用。在这里，我们评估了急性可卡因对静息状态和刺激反应的影响，以研究可卡因对神经血管偶联的影响，并将其对神经元活性的影响与其血管活性作用区分开来。我们同时测量皮质场电位通过薄颅脑电图记录和CBF与激光多普勒血流仪在大鼠的躯体感觉皮层的静息状态和前爪刺激之前和之后可卡因管理（1毫克/千克，静脉注射）。结果表明，可卡因使静息态场电位和脑血流量均降低（分别为19.8 ± 4.7%和52.1 ± 13.4%），且两者之间有很强的相关性（r = 0.81，P <0.01）。
Cocaine affects neuronal activity and constricts cerebral blood vessels, making it difficult to determine whether cocaine-induced changes in cerebral blood flow (CBF) reflect neuronal activation or its vasoactive effects. Here we assessed the effects of acute cocaine on both resting-state and stimulation responses to investigate cocaine's effects on neurovascular coupling and to differentiate its effects on neuronal activity from its vasoactive actions. We concurrently measured cortical field potentials via thinned-skull electroencephalography recordings and CBF with laser Doppler flowmetry in the rat's somatosensory cortex for both resting state and forepaw stimulation before and following cocaine administration (1 mg kg(-1), intravenously). Results show both resting-state field potentials and CBF were depressed after cocaine administration (19.8 +/- 4.7% and 52.1 +/- 13.4%, respectively) and these changes were strongly correlated with each other (r = 0.81, P