Plasma cysteinylglycine levels. and breast cancer risk in women
Plasma cysteinylglycine levels. and breast cancer risk in women
复制标题
DOI：
10.1158/0008-5472.can-07-3061
复制
发表时间：
2007-12-01
期刊：
影响因子：
11.2
通讯作者：
Zhang, Shumin M.
中科院分区：
文献类型：
--
作者：
Lin, Jennifer;Manson, JoAnn E.;Zhang, Shumin M.
半胱氨酰甘氨酸是谷胱甘肽催化过程中产生的一种促氧化剂，可诱导氧化应激和脂质过氧化，导致人类癌症的发生。缺乏半胱氨酰甘氨酸状态与乳腺癌风险相关的观察数据。我们前瞻性地评估了812例女性健康研究中的病例对照对的血浆半胱氨酰甘氨酸水平和浸润性乳腺癌风险，这是一项评估中老年女性低剂量阿司匹林和维生素E的完整随机试验。我们还评估了氧化应激风险因素的影响，如维生素E分配、饮酒、肥胖和绝经后激素使用。Logistic回归控制匹配因素，以及其他乳腺癌的危险因素，用于估计相对风险（1111）和95%置信区间（95%CI）。所有统计检验均为双侧检验。我们没有观察到血浆半胱氨酰甘氨酸和浸润性乳腺癌风险之间的整体关联。然而，在高氧化应激组中，较高的半胱氨酰甘氨酸水平与乳腺癌风险增加略有相关。相对于最低组，半胱氨酰甘氨酸最高五分位组中的女性的多变量RR（95% CI）为1.64（1.01-2.66; P趋势=0.04）维生素E安慰剂组，2.51（1.01-6.24; P-trend=0.07）在高酒精摄入组（>= 9/天），和1.66（0.97-2.84; P-trend = 0.03）在超重和肥胖组。我们的研究结果表明，易受氧化应激影响的女性患乳腺癌的风险更大。
Cysteinylglycine, a prooxidant generated during the catabolism of glutathione, has been suggested to induce oxidative stress and lipid peroxidation, leading to the development of human cancers. Observational data relating cysteinylglycine status to breast cancer risk are lacking. We prospectively evaluated plasma cysteinylglycine levels and invasive breast cancer risk among 812 case-control pairs nested in the Women's Health Study, a completed randomized trial evaluating low-dose aspirin and vitamin E in middle-aged and older women. We additionally evaluated the effect modification by risk factors for oxidative stress, such as vitamin E assignment, alcohol consumption, obesity, and postmenopausal hormone use. Logistic regression controlling for matching factors, as well as other risk factors for breast cancer, was used to estimate relative risks (1111) and 95% confidence intervals (95% Cl). All statistical tests were two sided. We observed no overall association between plasma cysteinylglycine and invasive breast cancer risk. However, higher cysteinylglycine levels were marginally associated with an increased risk of breast cancer in the high oxidative stress groups. Women in the highest quintile group of cysteinylglycine relative to the lowest group had multivariate RRs (95% CIs) of 1.64 (1.01-2.66; P-trend=0.04) in the vitamin E placebo group, 2.51 (1.01-6.24; P-trend=0.07) in the high alcohol intake group (>= 9/day), and 1.66 (0.97-2.84; P-trend = 0.03) in the overweight and obese group. Our findings suggest that women who are susceptible to experiencing oxidative stress may be at a greater risk for developing breast cancer.