Polarity during tissue repair, a multiscale problem.
Polarity during tissue repair, a multiscale problem.
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组织修复过程中的极性是一个多尺度问题。
DOI：
10.1016/j.ceb.2019.07.015
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发表时间：
2020
影响因子：
7.5
通讯作者：
Guzmán-Herrera A
中科院分区：
文献类型：
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作者：
Guzmán-Herrera A
亮点细胞极性对于跨多个尺度的修复至关重要。极化细胞行为、细胞骨架和连接成分驱动修复。细胞水平的极性对于恢复和维持组织完整性至关重要。细胞极性影响组织力学，进而影响组织对损伤的反应方式。组织修复对所有生物体都至关重要，因为它可以保护组织的完整性和功能，并预防感染和疾病。它发生在从宏观到微观的多个尺度上。大多数驱动组织修复的机制依赖于集体细胞行为的正确极化，例如迁移和增殖，以及细胞骨架和连接成分的极化。此外，细胞极性的重建和维持对于组织的完全修复以及在稳态和修复过程中承受机械应力至关重要。最近的证据强调了细胞极性和组织力学之间相互作用的重要作用，这对于组织修复至关重要。
HighlightsCell polarity is essential for repair across multiple scales.Polarised cell behaviours, cytoskeletal and junctional components drive repair.Polarity at the cellular level is crucial to restore and maintain tissue integrity.Cell polarity affects tissue mechanics and, in turn, how a tissue responds to injury.Tissue repair is essential for all organisms, as it protects the integrity and function of tissues and prevents infections and diseases. It takes place at multiple scales, from macroscopic to microscopic levels. Most mechanisms driving tissue repair rely on the correct polarisation of collective cell behaviours, such as migration and proliferation, and polarisation of cytoskeletal and junctional components. Furthermore, re-establishment and maintenance of cell polarity are fundamental for a tissue to be fully repaired and for withstanding mechanical stress during homeostasis and repair. Recent evidence highlights an important role for the interplay between cell polarity and tissue mechanics that are critical in tissue repair.