Photodynamic therapy in dermatology
Photodynamic therapy in dermatology
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DOI：
10.1001/archderm.134.2.207
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发表时间：
1998-02-01
影响因子：
--
通讯作者：
Ruzicka, T
中科院分区：
文献类型：
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作者：
Fritsch, C;Goerz, G;Ruzicka, T
光动力疗法（PDT）使用外源施用的或内源形成的光敏剂，通过形成单线态氧和其他自由基来诱导细胞死亡。光动力疗法越来越多地用于治疗皮肤癌和其他适应症。PDT的疗效取决于光敏剂的结构、给药方式、光源和治疗程序。本文就PDT在皮肤科的临床和实验研究进展作一综述。在PDT研究中，研究最深入的底物是δ-氨基乙酰丙酸（ALA）。局部应用ALA的光动力疗法已被证明是非常有效的治疗皮肤肿瘤，通过使用病灶内形成的卟啉作为光敏剂。对于日光性角化病，已描述了最佳缓解率。δ-氨基乙酰丙酸-PDT在治疗浅表基底细胞癌和鳞状细胞癌中也是有效的。此外，ALA诱导的卟啉在伍德光下的荧光在肿瘤皮肤组织中是高度选择性的，并且提供了一种检测和描绘具有不明确边界的皮肤肿瘤的有用技术。
Photodynamic therapy (PDT) uses exogenously administered or endogenously formed photosensitizers activated by light to induce cell death via formation of singlet oxygen and other free radicals. Photodynamic therapy is increasingly used for the treatment of skin cancers and other indications. The efficacy of PDT depends on the structure of the photosensitizer, the administration modality, the light source, and the treatment procedure. We reviewed the most recent clinical and experimental developments in PDT research related to dermatology. The substrate under most intense investigation in PDT research is delta-aminolevulinic acid (ALA). Photodynamic therapy with topically applied ALA has been shown to be highly efficient in the treatment of cutaneous neoplasms by using intralesionally formed porphyrins as photosensitizers. For solar keratoses, best response rates have been described. delta-Aminolevulinic-PDT is also efficient in the treatment of superficial basal cell and squamous cell carcinomas. In addition, the fluorescence of ALA-induced porphyrins under a Wood light is highly selective in neoplastic cutaneous tissue and offers a useful technique in detecting and delineating skin tumors with ill-defined borders.