A motion-incorporated reconstruction method for gated PET studies
A motion-incorporated reconstruction method for gated PET studies
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DOI：
10.1088/0031-9155/51/15/012
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发表时间：
2006-08-07
影响因子：
3.5
通讯作者：
Mawlawi, Osama R.
中科院分区：
文献类型：
--
作者：
Qiao, Feng;Pan, Tinsu;Mawlawi, Osama R.
PET成像中的心脏和呼吸运动伪影传统上通过在门控模式下采集数据来解决。然而，门控PET图像的特征通常在于由于其低光子统计的高噪声含量。在本文中，我们提出了一种新的4D模型的PET成像系统，它可以将运动信息生成一个无运动的图像与所有采集的数据。进行了计算机模拟和体模研究，以测试这种方法的性能。计算机模拟基于在数据采集期间连续缩放的数字体模。另一方面，体模研究在一个水箱中使用了两个球体，所有球体都装满了F-18水。其中一个球体是静止的，而另一个以正弦方式移动，以模拟胸腔中的肿瘤运动。使用4D CT和门控PET采集数据。运动信息从4D CT图像中导出，然后用于4D PET模型中。两项研究均表明，该4D PET模型具有良好的运动补偿能力。在体模研究中，与相应的静态采集相比，这种方法将放射性浓度的定量误差降低了95%，而与相应的门控图像相比，信噪比提高了210%。
Cardiac and respiratory motion artefacts in PET imaging have been traditionally resolved by acquiring the data in gated mode. However, gated PET images are usually characterized by high noise content due to their low photon statistics. In this paper, we present a novel 4D model for the PET imaging system, which can incorporate motion information to generate a motion-free image with all acquired data. A computer simulation and a phantom study were conducted to test the performance of this approach. The computer simulation was based on a digital phantom that was continuously scaled during data acquisition. The phantom study, on the other hand, used two spheres in a tank of water, all of which were filled with F-18 water. One of the spheres was stationary while the other moved in a sinusoidal fashion to simulate tumour motion in the thorax. Data were acquired using both 4D CT and gated PET. Motion information was derived from the 4D CT images and then used in the 4D PET model. Both studies showed that this 4D PET model had a good motion-compensating capability. In the phantom study, this approach reduced quantification error of the radioactivity concentration by 95% when compared to a corresponding static acquisition, while signal-to-noise ratio was improved by 210% when compared to a corresponding gated image.