The respiratory effects of cannabis dependence in young adults
The respiratory effects of cannabis dependence in young adults
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DOI：
10.1046/j.1360-0443.2000.951116697.x
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发表时间：
2000-11-01
期刊：
影响因子：
6
通讯作者：
Sears, MR
中科院分区：
文献类型：
--
作者：
Taylor, DR;Poulton, R;Sears, MR
瞄准评估大麻依赖与年轻人呼吸道症状和肺功能之间的关系，同时控制吸烟的影响。设置和参与者。对1972/1973年出生于新西兰达尼丁的1037名受试者的出生队列中的943名21岁的年轻成人进行了研究。测量.进行标准化呼吸道症状问卷调查。进行肺量测定和乙酰甲胆碱激发试验。使用DSM-III-R标准确定大麻依赖性。对大麻依赖者、吸烟者和不吸烟者进行了描述性分析和比较。测量呼吸道症状、肺功能和气道高反应性（PC 20）的校正比值比。调查结果。91例受试者（9.7%）为大麻依赖者，264例（28.1%）为当前吸烟者。在控制烟草使用后，与大麻依赖相关的呼吸道症状包括：除感冒外的喘息、运动引起的呼吸短促、夜间醒来伴胸闷和清晨痰液产生。分别增加61%、65%、72%（均P
Aim. To evaluate the relationship between cannabis dependence and respiratory symptoms and lung function in young adults, while controlling for the effects of tobacco smoking. Setting and participants. Nine hundred and forty-three young adults from a birth cohort of 1037 subjects born in Dunedin, New Zealand in 1972/1973 were studied at age 21. Measurements. Standardized respiratory symptom questionnaires were administered. Spirometry and methacholine challenge tests were undertaken. Cannabis dependence was determined using DSM-III-R criteria. Descriptive analyses and comparisons between cannabis-dependent, tobacco-smoking and non-smoking groups were undertaken. Adjusted odds ratios for respiratory symptoms, lung function and airway hyper-responsiveness (PC20) were measured. Findings. Ninety-one subjects (9.7%) were cannabis-dependent and 264 (28.1%) were current tobacco smokers. After controlling for tobacco use, respiratory symptoms associated with cannabis dependence included: wheezing apart from colds, exercise-induced shortness of breath, nocturnal wakening with chest tightness and early morning sputum production. These were increased by 61%, 65%, 72% (all p