Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain.
Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain.
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DOI：
10.1016/0024-3205(95)02099-5
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发表时间：
1995-08
期刊：
影响因子：
6.1
通讯作者：
G. Wang;N. Volkow;J. Fowler;Y. Ding;J. Logan;S. Gatley;R. Macgregor;A. Wolf
中科院分区：
文献类型：
--
作者：
G. Wang;N. Volkow;J. Fowler;Y. Ding;J. Logan;S. Gatley;R. Macgregor;A. Wolf
We compared the sensitivity of two dopamine transporter (DAT) ligands ([C-11]cocaine and [C-11]d-threo-methylphenidate) for measurement of extrastriatal DAT availability using positron emission tomography (PET) on separated groups of 10 age matched male volunteers (age range, 21–49 years). DAT availability was obtained using the ratio of the distribution volume in the region of interest to that in the cerebellum (Bmax′Kd′+ 1 ). DAT availability measured with [C-11] d-threo-methylphenidate was highest in basal ganglia, followed by thalamus > temporal insula, cingulate > orbitofrontal, frontal and occipital cortices. A similar ranking order for DAT availability was obtained with [C-11]cocaine. Specific binding (Bmax′Kd′) of [C-11]cocaine in thalamus was 25–33% that of basal ganglia and [C-11]d-threo-methylphenidate in thalamus was 11–13% that of basal ganglia. The regional measures with [C-11]cocaine were significantly correlated with those of [C-11]d-threo-methylphenidate (p < 0.0001). These results document extrastriatal binding in human brain with two different DAT ligands.
