Disorders of Consciousness and N400 ERP Measures in Response to a Semantic Task
Disorders of Consciousness and N400 ERP Measures in Response to a Semantic Task
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DOI：
10.1176/appi.neuropsych.12090227
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发表时间：
2013-06-01
影响因子：
2.9
通讯作者：
Guarnerio, Chiara
中科院分区：
文献类型：
--
作者：
Balconi, Michela;Arangio, Roberta;Guarnerio, Chiara
意识障碍（DOC）近年来一直在研究。本研究采用电生理学方法（ERPs）来验证植物人和最小意识状态下语义语言加工的保存情况。18例被归类为VS或MCS，和20个对照组提交了一个语义联想任务与一致或不一致的词序列（听觉刺激）。N400峰值振幅增加额中央皮层区域内的患者和对照组的不一致序列的反应。因此，语义处理部分保留在VS和MCS患者。
Disorders of consciousness (DOC) have been studied in recent years. In the present research, electrophysiological measures (ERPs) were used to verify the preservation of semantic linguistic processes in vegetative states (VS) and minimal-consciousness state (MCS). Eighteen patients classified as VS or MCS, and 20 controls were submitted to a semantic associative task with congruous or incongruous word sequences (auditory stimuli). An increased N400 peak amplitude within the fronto-central cortical areas was shown in response to incongruous sequences for both patients and controls. Thus, semantic processing was partially preserved in both VS and MCS patients.