Smoking habits influence pain and functional and psychiatric features in fibromyalgia
Smoking habits influence pain and functional and psychiatric features in fibromyalgia
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DOI：
10.1016/j.jbspin.2010.07.018
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发表时间：
2011-05-01
期刊：
影响因子：
4.2
通讯作者：
Kim, Seong-Kyu
中科院分区：
文献类型：
--
作者：
Lee, Shin-Seok;Kim, Seong-Ho;Kim, Seong-Kyu
目的：许多流行病学数据表明，吸烟可能在慢性肌肉骨骼疼痛的疾病表现或严重程度中发挥作用。本研究的作者调查了吸烟对临床特征的影响，如疼痛，疲劳，功能障碍和精神病学特征在韩国人口与纤维肌痛综合征（FMS）。方法：共336例FMS患者连续参加了10个医疗中心，参加了韩国全国纤维肌痛调查。吸烟者分为目前吸烟者和不吸烟者。FMS评估工具包括压痛点、纤维肌痛影响问卷（FIQ）、36项医学结局研究简表健康调查表（SF-36）、简明疲劳量表（BFI）、简明抑郁量表（BDI）、状态-特质焦虑量表（STAI-1和STAI-2）、社会家庭支持和社会朋友支持。统计分析包括卡方检验、Fisher精确检验、Mann-Whitney U检验和多因素Logistic回归分析。在调整后，目前吸烟者和不吸烟者的压痛点数量（P = 0.037）、BFI（P = 0.026）、SF-36的一般健康状况（P = 0.028）、BDI（P = 0.014）、晕厥（P = 0.024）和反射性交感神经营养不良（P = 0.003）与吸烟习惯无关。随机分组的非吸烟者（n = 55）和吸烟者（n = 33）在压痛点数（P = 0.009）、总压痛点数（P = 0.032）、BDI（P = 0.038）、全身无力（P = 0.047）和反射性交感神经营养不良（P = 0.011）方面差异有统计学意义。此外，压痛点的数量（P = 0.027，OR = 1.379）与调整后的吸烟状况相关。在女性FMS患者中随机的非吸烟者（n = 45）和吸烟者（n = 22）之间的分析显示，FMS中的BDI与吸烟状态（P = 0.023，OR = 1.077）后logistic回归analysis.Conclusions：这项研究表明，吸烟习惯可能部分影响FMS患者的疼痛或功能和精神病学特征。吸烟对FMS临床特征的影响应在更大的研究人群中进行评估。(C)2010年法国rhumatologie协会。由Elsevier Masson SAS出版。All rights reserved.
Objective: Numerous epidemiologic data have shown that smoking may play a role in the disease manifestations or severity of chronic musculoskeletal pain. The authors of the present study investigated the effect of smoking on clinical features such as pain, fatigue, functional impairment, and psychiatric features in the Korean population with fibromyalgia syndrome (FMS).Methods: A total of 336 patients with FMS were consecutively enrolled from 10 medical centers which participated in the Korean national fibromyalgia survey. Smoking was divided into current smokers and non-smokers. Instruments of FMS assessment included tender points, Fibromyalgia Impact questionnaire (FIQ), 36-item Medical Outcomes Study Short-Form Health Survey (SF-36), Brief Fatigue Inventory (BFI), Brief Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI)-1 and STAI-2, and social family support and social friend support. Statistical analyses included Chi-square test, Fisher's exact test, Mann-Whitney U test, and multivariate logistic regression analysis.Results: Thirty-three patients (9.8%) out of 336 participants were current smokers. The number of tender points (P = 0.037), BFI (P = 0.026), general health of SF-36 (P = 0.028), BDI (P = 0.014), syncope (P = 0.024), and reflex sympathetic dystrophy (P = 0.003) showing significance between current smokers and nonsmokers were not associated with smoking habits after adjustment. The significance of the number of tender points (P = 0.009), scores of total tender points (P = 0.032), BDI (P = 0.038), general weakness (P = 0.047), and reflex sympathetic dystrophy (P = 0.011) was observed between randomized non-smokers (n = 55) and smokers (n = 33). In addition, the number of tender points (P = 0.027, OR = 1.379) was associated with smoking status after adjustment. The analysis between randomized non-smokers (n = 45) and smokers (n = 22) in female FMS patients showed that BDI in FMS was associated with smoking status (P = 0.023, OR = 1.077) after logistic regression analysis.Conclusions: This study revealed that smoking habits may, in part, influence pain or functional and psychiatric features in FMS patients. The impact of smoking on clinical features in FMS should be assessed in a larger study population. (C) 2010 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.