Oral premalignancy: new methods of detection and treatment.
Oral premalignancy: new methods of detection and treatment.
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DOI：
10.1007/s11912-006-0050-4
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发表时间：
2006-03-01
影响因子：
4.7
通讯作者：
Richards-Kortum, Rebecca
中科院分区：
文献类型：
--
作者：
Gillenwater, Ann;Papadimitrakopoulou, Vali;Richards-Kortum, Rebecca
口腔癌的发生是通过遗传损伤的逐步积累而进行的。由于口腔易于检查，并且已知口腔癌的风险因素，因此在浸润性口腔癌发展之前通过诊断和治疗癌前病变来改善患者预后的机会很大。本文综述了口腔癌前病变的检测和诊断以及早期口腔肿瘤治疗的新方法。这些技术和治疗的进步是非常需要的，以改善与口腔癌相关的不良结果，由于我们无法诊断和治疗这种疾病在早期，可治愈的阶段。
Oral carcinogenesis proceeds through a stepwise accumulation of genetic damage over time. Because the oral cavity is easy to examine and risk factors for oral cancer are known, there is great opportunity to improve patient outcomes through diagnosis and treatment of pre-malignant lesions before the development of invasive oral carcinoma. This review provides a summary of developments in detection and diagnosis of oral premalignant lesions and innovative approaches to management of early oral neoplasia. These technological and therapeutic advances are much needed to improve the poor outcomes associated with oral cancer due to our inability to diagnose and treat this disease at an early, curable stage.