Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation.
Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation.
复制标题
植物药提取物和生物碱在调节病毒感染和炎症方面的进展。
DOI：
10.2147/dddt.s299120
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Ti H;Zhuang Z;Yu Q;Wang S
无论是在发展中国家还是发达国家，病毒性传染病都是对人类健康的严重威胁。尽管从合成来源开发作为抗病毒药物的新药仍在继续，但药用植物继续为一些最重要的抗病毒药物提供基本原料。生物碱是一类具有药理活性的植物化合物，在性质上通常是碱性的。在这篇综述中，我们试图根据2009-2019年的文献，总结草本抗病毒研究的最新进展，使用活性植物化合物作为抗病毒药物的优势，以及生物碱引发的炎症反应，用于治疗流感、人类免疫缺陷病毒、单纯疱疹病毒、肝炎和柯萨奇病毒感染。使用相关关键词从PubMed、Google Scholar和Web of Science检索文章。特别是，从药用植物中提取的生物碱对抗炎作用的分子机制进行了鉴定和讨论。这一综述可为利用各种生物碱进行抗病毒治疗提供理论依据和方法。需要更多的研究来开发生物碱化合物作为抗病毒治疗剂和潜在的抗炎反应调节剂。
Viral infectious diseases are serious threats to human health in both developing and developed countries. Although there is the continued development of new drugs from synthetic sources as antiviral agents, medicinal plants continue to provide the basic raw materials for some of the most important antiviral drugs. Alkaloids are a class of pharmacologically active plant compounds that are usually alkaline in nature. In this review, we tried to summarize recent progress in herb-based antiviral research, the advantages of using active plant compounds as antiviral agents, and the inflammatory responses initiated by alkaloids, based on the literature from 2009 to 2019, for the treatment of conditions, including influenza, human immunodeficiency virus, herpes simplex virus, hepatitis, and coxsackievirus infections. Articles are retrieved from PubMed, Google Scholar, and Web of Science using relevant keywords. In particular, the alkaloids from medicinal plants responsible for the molecular mechanisms of anti-inflammatory actions are identified and discussed. This review can provide a theoretical basis and approaches for using various alkaloids as antiviral treatments. More research is needed to develop alkaloidal compounds as antiviral therapeutic agents and potential regulators of the anti-inflammatory response.