Mechanisms leading to the development of hormone-resistant prostate cancer
Mechanisms leading to the development of hormone-resistant prostate cancer
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DOI：
10.1016/j.ucl.2005.12.010
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发表时间：
2006-05-01
影响因子：
2.4
通讯作者：
Cookson, Michael S.
中科院分区：
文献类型：
--
作者：
Kasper, Susan;Cookson, Michael S.
晚期和转移性前列腺癌仍然是潜在的致命肿瘤。虽然雄激素剥夺治疗仍然是最有效的治疗方法，但进展为雄激素非依赖性的患者死于疾病。本文重点介绍了激素抵抗发展的机制，包括雄激素剥夺治疗期间雄激素受体的重新激活，癌症干细胞的作用，以及上皮-间充质转化细胞的出现，这些细胞具有增加的转移潜力。正是通过对这些机制的深入了解，才能开发出对抗这种疾病的新疗法。
Advanced and metastatic prostate cancers remain potentially lethal tumors. Although androgen deprivation therapy remains the most effective treatment, patients who progress to androgen independence die of their disease. This article focuses on the mechanisms by which hormone resistance develops, including the reactivation of androgen receptor during androgen deprivation therapy, the role of cancer stem cells, and the emergence of epithelial-mesenchymal transition cells, which have increased metastatic potential. It is through an enhanced understanding of these mechanisms that new therapies can be developed to combat this disease.