Stress and psychiatric disorders
Stress and psychiatric disorders
复制标题
压力和精神疾病
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
C. Nemeroff
中科院分区：
文献类型：
--
作者：
S. C. Stout;C. Nemeroff
长期以来，人们一直认为急性和/或慢性生活压力源在许多精神疾病的发病机制和症状恶化中发挥作用。一些证据从生活事件研究支持压力和精神疾病之间的联系进行了审查。证据表明，下丘脑-垂体-肾上腺（HPA）轴，特别是促肾上腺皮质激素释放因子（CRF）的一般失调，哺乳动物应激反应的中心介质，在情绪和焦虑障碍的病理生理学中起着重要作用。
Abstract Acute and/or chronic life stressors have long been postulated to play a role in the pathogenesis of numerous psychiatric diseases and in the exacerbation of symptoms. Some of the evidence from life events research supporting a link between stress and psychiatric disease is reviewed. The evidence that in general dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and specifically of corticotropin-releasing factor (CRF), the central mediator of the mammalian stress response, plays a pre-eminent role in the pathophysiology of mood and anxiety disorders is described.