Mechanical and structural analysis of the pulmonary valve in congenital heart defects: A presentation of two case studies.
Mechanical and structural analysis of the pulmonary valve in congenital heart defects: A presentation of two case studies.
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DOI：
10.1016/j.jmbbm.2018.08.053
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发表时间：
2019-01
影响因子：
3.9
通讯作者：
Sun W
中科院分区：
文献类型：
--
作者：
Sulejmani F;Pokutta-Paskaleva A;Salazar O;Karimi M;Sun W
先天性心脏病 (CHD) 是儿科死亡的主要原因，许多病例影响右心室流出道 (RVOT) 或肺动脉瓣 (PV)。了解疾病的机制可以深入了解耐用修复技术和生物工程替代设备的开发。这项工作对两个儿科病例的肺动脉瓣进行了机械和结构分析。作为手术过程的一部分，切除了两个 PV 组织。一份 PV 取自一名患有努南综合征的 9 个月大婴儿（患者 1），另一份取自一名患有三尖瓣闭锁的 6 个月大婴儿（患者 2）。对小叶进行平面双轴拉伸测试和二次谐波发生 (SHG) 成像，以进行机械和结构评估。患者 1 表现出比患者 2 更强的各向异性机械响应，样品刚度与成人 PV 组织相当。此外，两个样本均显示出小叶心室侧和纤维侧的胶原纤维分别呈径向和圆周排列。纤维侧的胶原纤维也比心室侧的胶原纤维更卷曲。
Congenital Heart Disease (CHD) is the leading cause of pediatric mortality, with many cases affecting the right ventricular outflow tract (RVOT) or pulmonary valve (PV). Understanding the mechanics of the disease condition can provide insight into development of durable repair techniques and bioengineered replacement devices. This work presents a mechanical and structural analysis of the pulmonary valve of two pediatric cases. Two PV tissues were excised as part of the operative procedure. One PV was obtained from a 9-month- old with Noonan syndrome (Patient 1) and the other from a 6-month-old with tricuspid atresia (Patient 2). The leaflets were subjected to planar biaxial tensile testing and second harmonic generation (SHG) imaging for mechanical and structural evaluation. Patient 1 exhibited a more anisotropic mechanical response than Patient 2, with sample stiffness on par with that of adult PV tissue. Additionally, both samples showed radial and circumferential alignment of collagen fibers on the ventricularis and fibrosa sides of the leaflets, respectively. Collagen fibers on the fibrosa side were also more crimped than on the ventricularis side.
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影响因子：
14
作者：
Engelmayr, GC;Hildebrand, DK;Sacks, MS
通讯作者：
Sacks, MS
影响因子：
2.7
作者：
Patterson JT;Gilliland T;Maxfield MW;Church S;Naito Y;Shinoka T;Breuer CK
通讯作者：
Breuer CK
影响因子：
9.7
作者：
Thuy Pham;Sulejmani, Fatiesa;Sun, Wei
通讯作者：
Sun, Wei
DOI：
10.1067/mje.2002.126821
发表时间：
2002-12-01
影响因子：
6.5
作者：
Weinberg, CE;Hertzberg, JR;Shandas, R
通讯作者：
Shandas, R
影响因子：
6
作者：
Phillippi, Julie A.;Green, Benjamin R.;Eskay, Michael A.;Kotlarczyk, Mary P.;Hill, Michael R.;Robertson, Anne M.;Watkins, Simon C.;Vorp, David A.;Gleason, Thomas G.
通讯作者：
Gleason, Thomas G.