Hydrogen sulphide and tempol treatments improve the blood pressure and renal excretory responses in spontaneously hypertensive rats
Hydrogen sulphide and tempol treatments improve the blood pressure and renal excretory responses in spontaneously hypertensive rats
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DOI：
10.3109/0886022x.2014.882218
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发表时间：
2014-05-01
期刊：
影响因子：
3
通讯作者：
Johns, Edward J.
中科院分区：
文献类型：
--
作者：
Ahmad, Fiaz Ud Din;Sattar, Munavvar A.;Johns, Edward J.
氧化应激和抑制H2S的产生导致肾血管阻力增加，肾小球血流动力学紊乱，以及肾钠和水处理异常，有助于人类和自发性高血压大鼠原发性高血压的发病和维持。本研究探讨了硫化氢和tempol单独和联合对血压和肾脏血流动力学和排泄功能的影响。WKY大鼠组或SHR组（n=6）作为对照或接受NaHS（SHR + NaHS）、Tempol（SHR + Tempol）或NaHS + Tempol（SHR + NaHS + Tempol）治疗4周。在第0、14和28天进行代谢研究，之后将动物麻醉以测量肾血流动力学和血浆氧化和抗氧化标记物。与WKY相比，SHR对照组大鼠的平均动脉血压更高（140.0 +/- 2 vs. 100.0 +/- 3 mmHg），血浆和尿H2S、肌酐清除率、尿流速和尿钠排泄量以及氧化应激水平更低（均为p
Oxidative stress and suppressed H2S production lead to increased renal vascular resistance, disturbed glomerular hemodynamics, and abnormal renal sodium and water handling, contribute to the pathogenesis and maintenance of essential hypertension in man and the spontaneously hypertensive rat. This study investigated the impact of H2S and tempol alone and in combination on blood pressure and renal hemodynamics and excretory functions in the SHR. Groups of WKY rats or SHR (n=6) were treated for 4 weeks either as controls or received NaHS (SHR + NaHS), tempol (SHR + Tempol), or NaHS plus tempol (SHR + NaHS + Tempol). Metabolic studies were performed on days 0, 14, and 28, thereafter animals were anaesthetized to measure renal hemodynamics and plasma oxidative and antioxidant markers. SHR control rats had higher mean arterial blood pressure (140.0 +/- 2 vs. 100.0 +/- 3 mmHg), lower plasma and urinary H2S, creatinine clearance, urine flow rate and urinary sodium excretion, and oxidative stress compared to WKY (all p