Perfusion imaging using dynamic arterial spin labeling (DASL)
Perfusion imaging using dynamic arterial spin labeling (DASL)
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DOI：
10.1002/mrm.1136
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发表时间：
2001-06-01
影响因子：
3.3
通讯作者：
Koretsky, AP
中科院分区：
文献类型：
--
作者：
Barbier, EL;Silva, AC;Koretsky, AP
最近，已经引入了一种基于动脉自旋标记的技术，称为动态动脉自旋标记（DASL（Magn Reson Med 1999;41：299-308）），以同时测量标记的血液从标记平面到交换部位的通过时间、组织的纵向弛豫时间和组织的灌注。该技术依赖于测量组织磁化响应于随时间变化的标记函数。对组织磁化响应的特性（渡越时间、填充时间常数和灌注）的分析允许对组织灌注进行量化和渡越时间图计算。在目前的工作中，DASL计划被用来在conjalent与回波平面成像在4.7 T产生脑地图的灌注和渡越时间在麻醉大鼠，分级高碳酸血症。获得的数据显示灌注和通过时间的变化作为动脉pCO（2）的函数。基于这些数据，计算CO2反应性图。出版于2001年Wiley-Liss，Inc.（匕首）。
Recently, a technique based on arterial spin labeling, called dynamic arterial spin labeling (DASL (Magn Reson Med 1999;41:299-308)), has been introduced to measure simultaneously the transit time of the labeled blood from the labeling plane to the exchange site, the longitudinal relaxation time of the tissue, and the perfusion of the tissue. This technique relies on the measurement of the tissue magnetization response to a time varying labeling function. The analysis of the characteristics of the tissue magnetization response (transit time, filling time constant, and perfusion) allows for quantification of the tissue perfusion and for transit time map computations. In the present work, the DASL scheme is used in conjuction with echo planar imaging at 4.7 T to produce brain maps of perfusion and transit time in the anesthetized rat, under graded hypercapnia. The data obtained show the variation of perfusion and transit time as a function of arterial pCO(2), Based on the data, CO2 reactivity maps are computed. Published 2001 Wiley-Liss, Inc.(dagger).