Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS).
Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS).
复制标题
通过实时 AccuTOFTM 质谱 (DART-MS) 直接分析，通过质量保证和转移程序鉴定肠外药物制剂中的药物。
DOI：
10.1093/jat/bkw065
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发表时间：
2016
影响因子：
2.5
通讯作者：
Peace,MichelleR
中科院分区：
文献类型：
--
作者：
Poklis,JustinL;Mohs,AmandaJ;Wolf,CarlE;Poklis,Alphonse;Peace,MichelleR
在医疗机构中，药物转移和医生的损害是主要的 需要一种快速有效的监测和检测方法。 采用真实的实时直接分析离子源与JEOL AccuTOFT飞行时间质谱仪联用的方法， 用于潜在药物转移的肠胃外药物制剂。肠胃外 药物制剂也称为可注射制剂， 与静脉内、皮下、肌内和关节内联合使用 局使用由质谱仪收集的质谱数据创建文库。 DART-MS在20、60和90 V设置下以开关模式运行。此库 包含17种胃肠外药物中常见的药物 包括手术镇痛剂的制剂：芬太尼、氢吗啡酮和 吗啡;麻醉剂：巴氯芬、布比卡因、氯胺酮、咪达唑仑、罗哌卡因 和琥珀酰胆碱;以及其他药物类别的混合物：咖啡因，可乐定， 地塞米松、麻黄碱、肝素、美沙酮、催产素和苯肾上腺素。 随机选择200种去识别胃肠外药物制剂 将含有一种或多种药物的样品提交给FIRM毒理学部门进行分析 在弗吉尼亚联邦大学健康实验室， DART-MS。去识别制剂的药物内容物先前已 通过公开的高效液相色谱（HPLC）方法证实。 制剂中的药物使用快速且成功地鉴定， 生成库。DART-MS和HPLC结果完全一致。 所有200种肠胃外药物制剂。
In healthcare settings drug diversion and impairment of physicians are major concerns requiring a rapid and efficient method for surveillance and detection. A Direct Analysis in Real Time ion source coupled to a JEOL AccuTOFTMtime-of-flight mass spectrometer (DART-MS) method was developed to screen parenteral pharmaceutical formulations for potential drug diversion. Parenteral pharmaceutical formulations are also known as injectable formulations and are used with intravenous, subcutaneous, intramuscular and intra-articular administration. A library was created using the mass spectra data collected by a DART-MS operated in switching mode at 20, 60 and 90 V settings. This library contained 17 commonly encountered drugs in parenteral pharmaceutical formulations that included the surgical analgesic: fentanyl, hydromorphone and morphine; anesthetic: baclofen, bupivacaine, ketamine, midazolam, ropivacaine and succinylcholine; and a mixture of other drug classes: caffeine, clonidine, dexamethasone, ephedrine, heparin, methadone, oxytocin and phenylephrine. Randomly selected 200 de-identified parenteral pharmaceutical formulations containing one or more drugs were submitted for analysis to the FIRM Toxicology Laboratory at Virginia Commonwealth University Health and were screened using the DART-MS. The drug contents of the de-identified formulations were previously confirmed by a published high performance liquid chromatography (HPLC) method. The drugs in the formulations were rapidly and successfully identified using the generated library. The DART-MS and HPLC results were in complete agreement for all 200 parenteral pharmaceutical formulations.