S100 proteins in cancer.
S100 proteins in cancer.
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DOI：
10.1038/nrc3893
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发表时间：
2015-02
影响因子：
78.5
通讯作者：
Zimmer, Danna B.
中科院分区：
文献类型：
--
作者：
Bresnick, Anne R.;Weber, David J.;Zimmer, Danna B.
在人类中，S100蛋白家族由21个成员组成，这些成员表现出高度的结构相似性，但在功能上不可互换。该蛋白质家族通过作为细胞内Ca2+传感器和细胞外因子来调节细胞反应。S100家族多个成员的表达失调是人类癌症的共同特征，每种类型的癌症都显示出独特的S100蛋白质谱或特征。新出现的体内证据表明，大多数S100蛋白的生物学是复杂和多因素的，并且这些蛋白积极地促进肿瘤发生过程，如细胞增殖、转移、血管生成和免疫逃避。药物发现工作已经确定了抑制几个S100家族成员的线索，其中两个已确定的抑制剂已在癌症患者中进行临床试验。本综述重点介绍了S100家族成员在癌症诊断和治疗中的作用、S100信号对肿瘤生物学的贡献以及S100抑制剂治疗癌症的发现和开发。
In humans, the S100 protein family is composed of 21 members that exhibit a high degree of structural similarity, but are not functionally interchangeable. This family of proteins modulates cellular responses by functioning both as intracellular Ca2+ sensors and as extracellular factors. Dysregulated expression of multiple members of the S100 family is a common feature of human cancers, with each type of cancer showing a unique S100 protein profile or signature. Emerging in vivo evidence indicates that the biology of most S100 proteins is complex and multifactorial, and that these proteins actively contribute to tumorigenic processes such as cell proliferation, metastasis, angiogenesis and immune evasion. Drug discovery efforts have identified leads for inhibiting several S100 family members, and two of the identified inhibitors have progressed to clinical trials in patients with cancer. This Review highlights new findings regarding the role of S100 family members in cancer diagnosis and treatment, the contribution of S100 signalling to tumour biology, and the discovery and development of S100 inhibitors for treating cancer.
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影响因子：
3.7
作者：
Björk P;Källberg E;Wellmar U;Riva M;Olsson A;He Z;Törngren M;Liberg D;Ivars F;Leanderson T
通讯作者：
Leanderson T
影响因子：
64.5
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作者：
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通讯作者：
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
8
作者：
Ambartsumian, N;Klingelhöfer, J;Lukanidin, E
通讯作者：
Lukanidin, E