Stimulation Parameters Define the Effectiveness of Burst Spinal Cord Stimulation in a Rat Model of Neuropathic Pain
Stimulation Parameters Define the Effectiveness of Burst Spinal Cord Stimulation in a Rat Model of Neuropathic Pain
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DOI：
10.1111/ner.12221
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发表时间：
2015-01-01
期刊：
影响因子：
2.8
通讯作者：
Winkelstein, Beth A.
中科院分区：
文献类型：
--
作者：
Crosby, Nathan D.;Keiser, Melanie D. Goodman;Winkelstein, Beth A.
虽然有报道称脊髓破裂刺激（SCS）可以减轻神经性疼痛，但没有研究明确地研究了定义脊髓破裂刺激的不同参数如何调节其疗效。在颈神经根病大鼠模型中，通过改变刺激参数来评估突发SCS减少神经元对有害刺激反应的有效性。方法观察颈神经根压迫疼痛后第7天脊髓脊髓破裂前后脊髓背角神经元放电情况。定义刺激的参数（每次脉冲数、脉冲频率、脉冲宽度、脉冲频率、幅度）在单独的刺激试验中单独变化，而其余参数保持不变。研究人员量化了各参数下宽动态范围（WDR）和高阈值神经元放电减少的百分比，以及对SCS作出反应的神经元的百分比，并将其与刺激过程中每次放电的电荷相关联。结果脉搏数、脉宽、幅值均有显著相关性(p
IntroductionAlthough burst spinal cord stimulation (SCS) has been reported to reduce neuropathic pain, no study has explicitly investigated how the different parameters that define burst SCS may modulate its efficacy. The effectiveness of burst SCS to reduce neuronal responses to noxious stimuli by altering stimulation parameters was evaluated in a rat model of cervical radiculopathy.MethodsNeuronal firing was recorded in the spinal dorsal horn before and after burst SCS on day 7 following painful cervical nerve root compression (N = 8 rats). The parameters defining the stimulation (number of pulses per burst, pulse frequency, pulse width, burst frequency, amplitude) were individually varied in separate stimulation trials while holding the remaining parameters constant. The percent reduction of firing of wide-dynamic-range (WDR) and high-threshold neurons after SCS and the percentage of neurons responding to SCS were quantified for each parameter and correlated to the charge per burst delivered during stimulation.ResultsPulse number, pulse width, and amplitude each were significantly correlated (p