The long term prognostic significance of c-erbB-2 in primary breast cancer.
The long term prognostic significance of c-erbB-2 in primary breast cancer.
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DOI：
10.1038/bjc.1991.103
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发表时间：
1991-03
影响因子：
8.8
通讯作者：
Rudland PS
中科院分区：
文献类型：
--
作者：
Winstanley J;Cooke T;Murray GD;Platt-Higgins A;George WD;Holt S;Myskov M;Spedding A;Barraclough BR;Rudland PS
采用免疫组织化学技术，用21 N多克隆抗体对1975-1981年间接受治疗的465例I期和II期乳腺癌患者石蜡包埋组织中c-erbB-2癌基因的表达进行了评价。104例（22%）患者显示阳性染色。这与其他变量无关。癌基因的表达与显著较差的生存率相关，这与其他肿瘤变量无关。
The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.