Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery
Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery
复制标题
DOI：
10.1161/01.hyp.33.5.1105
复制
发表时间：
1999-05-01
期刊：
影响因子：
8.3
通讯作者：
Berthelot, A
中科院分区：
文献类型：
--
作者：
Laurant, P;Hayoz, D;Berthelot, A
本研究旨在探讨低镁饮食(80 mg/kg与对照饮食960 mg/kg)对大鼠血压及颈总动脉力学性能的影响。用回声跟踪仪连续测量颈动脉内径和动脉内压。在19周时，镁缺乏的大鼠的收缩压、舒张压和平均血压较高。组织学检查显示缺镁大鼠颈动脉横截面积、内中膜厚度和中腔比增加。镁缺乏不改变动脉扩张性-血压曲线。在平均血压下，对照组和缺镁组19周龄大鼠的动脉扩张性明显低于5周龄大鼠。年龄与低镁饮食对动脉扩张性的交互作用显著(P
The purpose of this study was to determine the effect of dietary Mg deficiency (80 mg/kg versus control diet: 960 mg/kg) on blood pressure and mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously with an echo-tracking device. At 19 weeks, systolic, diastolic, and mean blood pressures were higher in Mg-deficient rats. Histological examination showed an increase in cross-sectional area, intima-media thickness, and media-to-lumen ratio in carotid artery of Mg-deficient rats. Mg deficiency did not modify the arterial distensibility-blood pressure curve. At mean blood pressure, arterial distensibility was significantly less in 19-week-old rats than in 5-week-old rats of both control and Mg-deficient groups. A significant interaction between age and Mg-deficient diet on arterial distensibility (P