Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial
Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial
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DOI：
10.1200/jco.2014.57.2909
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发表时间：
2014-12-01
影响因子：
45.3
通讯作者：
Mehta, Minesh P.
中科院分区：
文献类型：
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作者：
Gondi, Vinai;Pugh, Stephanie L.;Mehta, Minesh P.
目的全脑放疗（WBRT）中海马神经干细胞损伤可能在记忆减退中起作用。调强放疗可用于避免适形海马神经干细胞室在WBRT（HA-WBRT）。RTOG 0933是一个单臂第二阶段的研究HA-WBRT脑转移与预先指定的比较与WBRT治疗的患者没有海马avoidation.Patients和MethodsEligible成人脑转移患者接受HA-WBRT到30戈伊在10个分数的历史对照。在基线和2、4、6个月时进行标准化认知功能和生活质量（QOL）评估。主要终点是4个月时的霍普金斯言语学习测试-修订的延迟回忆（HVLT-R DR）。历史对照显示HVLT-R DR从基线至4个月平均相对下降30%。检测平均相对下降
PurposeHippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT). RTOG 0933 was a single-arm phase II study of HA-WBRT for brain metastases with prespecified comparison with a historical control of patients treated with WBRT without hippocampal avoidance.Patients and MethodsEligible adult patients with brain metastases received HA-WBRT to 30 Gy in 10 fractions. Standardized cognitive function and quality-of-life (QOL) assessments were performed at baseline and 2, 4, and 6 months. The primary end point was the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT-R DR) at 4 months. The historical control demonstrated a 30% mean relative decline in HVLT-R DR from baseline to 4 months. To detect a mean relative decline