DETRIMENTS IN NEURON MORPHOLOGY FOLLOWING HEAVY ION IRRADIATION: WHAT'S THE TARGET?
DETRIMENTS IN NEURON MORPHOLOGY FOLLOWING HEAVY ION IRRADIATION: WHAT'S THE TARGET?
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重离子辐照后神经元形态的损害：目标是什么？
DOI：
10.1093/rpd/ncy265
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发表时间：
2019
影响因子：
1
通讯作者：
EliedonnaCacao,MuratAlp
中科院分区：
文献类型：
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作者：
Cucinotta,FrancisA;EliedonnaCacao,MuratAlp
神经元细胞由索马或胞体、轴突、具有多个分支的树突和树突棘组成，它们是记忆储存和突触传递的基质。神经元形态学的损伤被认为在脑辐射后的认知障碍中起关键作用。神经元形态的调节和稳定涉及多种分子机制，而辐射对这些过程的影响尚未得到广泛研究。在这份报告中，我们认为可能的生物目标，在神经元的能量沉积（艾德）的带电粒子，可能会导致神经元形态学的损害，以及由此产生的剂量和辐射质量的依赖性，这种损害。重离子的径迹结构由高艾德事件的核和靶分子电离产生的δ射线电子的稀疏艾德半影组成。我们认为轨道结构的作用相对于可能的目标的原因在退化的形态。
Neuron cells consist of the soma or cell body, axons, dendritic arbor with multiple branches, and dendritic spines which are the substrates for memory storage and synaptic transmission. Detriments in neuron morphology are suggested to play a key role in cognitive impairments following brain irradiation. Multiple molecular mechanisms are involved in the regulation and stability of neuron morphology, while the effects of radiation on these processes have not been studied extensively. In this report, we consider possible biological targets in neurons for energy deposition (ED) by charged particles that could lead to neuron morphology detriments, and the resulting dose and radiation quality dependence of such detriments. The track structures of heavy ions including high charge and energy (HZE) particles consists of core of high-ED events and a penumbra of sparse ED from δ-ray electrons produced in ionization of target molecules. We consider the role of track structure relative to possible targets causative in the degradation of morphology.